Epigenetics and Metabolomics, a new volume in the Translational Epigenetics series, offers a synthesized discussion of epigenetic control of metabolic activity, and systems-based approaches for better understanding these mechanisms. Over a dozen chapter authors provide an overview of epigenetics in translational medicine and metabolomics techniques, followed by analyses of epigenetic and metabolomic linkage mechanisms likely to result in effective identification of disease biomarkers, as well as new therapies targeting the removal of the inappropriate epigenetic alterations. Epigenetic interventions in cancer, brain damage, and neuroendocrine disease, among other disorders, are discussed in-depth, with an emphasis on exploring next steps for clinical translation and personalized healthcare. Offers a synthesized discussion of epigenetic regulation of metabolic activity and systems-based approaches to power new researchDiscusses epigenetic control of metabolic pathways and possible therapeutic targets for cancer, neurodegenerative, and neuroendocrine diseases, among othersProvides guidance in epigenomics and metabolomic research methodology INDICE: 1. Epigenetics in translational Medicine2. Metabolomics techniques: A brief Update3. Integration of epigenomics and metabolomics: From biomarkers discovery to personalized medicine4. Epigenetic Regulation of Oncogenes5. Epigenetics and Metabolism in Neurodegenrative diseases6. Genome-wide identification and transcriptional analysis of diphthamide biosynthesis pathway in malaria parasite7. Radiation responsive metabolic alterations: An update8. Epigenetic and metabolic changes in Blast induced traumatic brain injury9. Recent advances of epigenetics in plant sciences10. Plant derived HDAC inhibitor chrysin in anticancer therapy11. Epigenetic regulation of neuronal development and function
- ISBN: 978-0-323-85652-2
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 360
- Fecha Publicación: 01/08/2021
- Nº Volúmenes: 1
- Idioma: Inglés