Combating fungal infections: problems and remedy

The currently available means of combating fungal infections are weak and clumsy. The application of fungal genomics offers an unparalleled opportunity to develop novel antifungal drugs. Interestingly, several novel antifungal drug targets have already been identified and validated. However, it is premature toexpect a novel antifungal agent in clinical setting as drug discovery programs are still in their infancy. In addition to classical and genomic approaches to drug discovery, treasure trove based on natural products and phytomedicine can provide a multitude of alternative modes of combating fungal infection. This book incisively addresses essential topics on various aspects pertaining tofungal diseases in human and animals, their reservoir, fungal pathogenesis, their management and recent advances in their treatment. Issues of antifungal drug toxicity, especially nephrotoxicity, are also discussed. The development of resistance in fungal pathogens, including multidrug resistance and its mechanism, is dealt with in two chapters. Diverse diagnostic approaches to fungal infections are also reviewed. The combinational drug strategies used in combating invasive fungal infections are addressed in detail. The management of pulmonary mycoses in stem cell transplantation is also given special focus. Novel antifungal drugs (synthetic and herbal), fungal vaccines, and metabolic pathways as drug targets are discussed in detail in three different chapters. Subsequently the roles of innate immunity, cytokine therapy and immunomodulators in the treatment of fungal infections are elaborated upon. As novel drug delivery systems have a great potential for modifying the pharmacokinetics of medications, the last chapter takes this fact into consideration in its examination of state-of-the-art delivery systems in controlling fungal infections. Unique as it gives an overall comprehensive holistic approach and recent developments incombating fungal infections Special focus is given to the management of pulmonary mycoses in stem cell transplantation Issues of antifungal drug toxicity are discussed INDICE: Mould Infections: A global Threat to Immunocompromised Patients.- Virulence and Pathogenicity of Fungal Pathogens with Special Reference to Candida albicans.- Animal as Reservoir of Fungal Diseases (Zoonoses).- Fungi Associated with Eye Infections with Special Reference to Corneal Keratitis and Their Possible Reservoir.- Antifungal Drugs: Mode of Action and Recent Development.- Antifungal-induced Nephrotoxicity in Pediatrics: A State of Art.- Antifungal Resistance: Cellular and Molecular Mechanisms.- Multidrug Resisitance in Fungi: Role of Pleiotropic Drug Resistance Genes.- Laboratory Diagnosis of FungalInfections: An Overview.- Combinational Antifungal Therapy and Recent Trends in Drug Discovery.- Role of De-escalation and Combination Therapy Strategies in the Management of Invasive Fungal Infection: A Multidisciplinary Point of View.- Challenges to the Management of Pulmonary Mycoses in Allogeneic Hematopoietic Stem Cell Transplantation.- Aspartic Peptidase Inhibitors as Potential Bioactive Pharmacological Compounds Against Human Fungal Pathogens.- Metabolic Pathways as Drug Targets: Targeting the Sulphur Assimilatory Pathways of Yeast and Fungi for Novel Drug Discovery.- Innate Immunity in Pathogenesis and Treatment of Dermatomycoses.- Cytokines Therapy: Possible Tools in Management of Fungal Infection.- Immunomodulators: Potential in Treatment of Systemic Fungal Infections.- Fungal Vaccines: Recent Trends.- Antifungal Activity of Medicinal Plant Extracts and Phytocompounds: A Review.- Novel Drug Delivery Systems for Antifungal Compounds

• ISBN: 978-3-642-12172-2
• Editorial: Springer
• Encuadernacion: Cartoné
• Páginas: 505
• Fecha Publicación: 01/07/2010
• Nº Volúmenes: 1
• Idioma: Inglés