Epigenetics and Neuroplasticity - Evidence and Debate

The 'epi-(Greek for 'over', 'above')genome', with its rich cache of highly regulated, structural modifications-including DNA methylation, histone modifications and histone variants-defines the moldings and three-dimensional structures of the genomic material inside the cell nucleus and serves, literally, as a molecular bridge linking the environment to the genetic materials in our brain cells. Due to technological and scientific advances in the field, the field of neuroepigenetics is currently one of the hottest topics in the basic and clinical neurosciences. The volume captures some of this vibrant and exciting new research, and conveys to the reader an up-to-date discussion on the role of epigenetics across the lifespan of the human brain in health and disease. Topics cover the entire lifespan of the brain, from transgenerational epigenetics to neurodevelopmental disease to disorders of the aging brain. All chapters are written with dual intent, to provide the reader with a timely update on the field, and a discussion of provocative or controversial findings in the field with the potential of great impact for future developments in the field. INDICE: Epigenetic Mechanisms in Memory Formation and StorageFarah Lubin Transgenerational Epigenetics IIJanina Galler    The Rubinstein-Taybi syndrome, a paradigm of neurodevelopmental disorder with an epigenetic originAngel Barco  Epigenetics and the aging brainAndre Fischer  Epigenetics in post-traumatic stress disorderElisabeth Binder and Nadine Provençal   Histone-mediated Epigenetics in AddictionMatthew Lattal    Epigenetics of SchizopheniaAlessandro GuidottiEpigenetics of DepressionRobert Lipsky  REST and Histone-mediated epigenetics in EpilepsyAvtar Roopra   DNA methylation-mediated Epigenetics in EpilepsyHongjun Song  Epigenetic protocols: Challenges and limitations in the central nervous systemMichelle Amaral   Future Directions of NeuroepigeneticsSchahram Akbarian 

• ISBN: 978-0-12-800977-2
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 656
• Fecha Publicación: 12/11/2014
• Nº Volúmenes: 1
• Idioma: Inglés