Viral Vectors in Cancer Immunotherapy

International Review of Cell and Molecular Biology Volume 379 presents Viral Vectors in Cancer Immunotherapy. Cancer immunotherapy has transformed cancer treatment through advances in immune checkpoint inhibitors and adoptive cell therapy. However, new therapeutic strategies are needed to boost the immune system in patients who do not benefit from current treatments. The use of genetically modified viruses allows the expression of pro-inflammatory molecules, while the immune system receives danger signals from the viruses themselves. In some cases, the virus can also induce tumor cell death. This book will review advances in virus-based cancer immunotherapy in both solid tumors and hematologic malignancies. The general chapters will provide an overview of the landscape of virotherapy for solid tumors and hematologic malignancies Specific chapters will review advances in alphaviruses, adenoviruses, vaccinia viruses, and Maraba virus The chapter will provide lessons on how to improve viruses to enhance immune responses INDICE: 1. Past, present and future of viral vectors in cancer immunotherapySanjay Rathod2. Alphaviruses in cancer immunotherapyKenneth Lundstrom3. Adenoviral-based cancer gene therapyMarta M. Alonso4. Armored modified vaccinia Ankara in cancer immunotherapyMaria Hinterberger5. Strategies of Semliki Forest virus in immuno-oncologyCristian Smerdou6. Maraba virus in cancer immunotherapyJonathan Pol7. Oncolytic viruses in hematological malignanciesVera Machado8. Oncolytic virus for cancer therapies: Overview and future directionsRupsa Basu

• ISBN: 978-0-443-19249-4
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 277
• Fecha Publicación: 01/08/2023
• Nº Volúmenes: 1
• Idioma: Inglés