Febrile Seizures: New Concepts and Consequences

Febrile Seizures: New Concepts and Consequences, Second Edition presents the latest developments and current state of knowledge in the field. Topics include new imaging tools and emerging data, the visualizing effects of febrile seizures on the brain, new genetic methodologies, and the use of animal models to permit scientific analysis of the electrophysiology and molecular biology of the seizure. This updated second edition covers many advances, such as the role of inflammation and the prediction of epilepsy across species. The editors also discuss the memory problems following long febrile seizures and critical new information derived from children and animal models. This book provides readers with a broad understanding of the spectrum of febrile seizure outcomes and the relevant mechanisms and biomarkers involved. Reviews all aspects of febrile seizures, including epidemiology, neurobiology and treatment Discusses novel and newly discovered information based on up-to the minute methods Provides an engaging style that is accessible to clinicians, researchers and educated parents INDICE: 1. Incidence and prevalence of febrile seizures 2. Who gets recurrent febrile seizures (also complex) 3. Outcomes of febrile seizures: cognitive and epileptogenesis: B. Genetic and Acquired Syndromes Associated with Febrile Seizures 4. The genetic landscape of febrile seizures and GEFS+ 5. SCN1A and Dravet syndrome 6. Other channel syndromes 7. FIRES and related syndromes C. Febrile Status Epilepticus 8. Epidemiology of FSE 9. Neuroimmune aspects of FSE 10. FSE and TLE 11. FSE and TLE- evolving therapeutic and surgical landscape 12. Cognitive outcome of FSE D. The Neurobiology of FS and FSE: experimental approaches 13. Why do febrile seizures involve the developing brain? 14. Cytokines in FS rat models 15. FS and FSE generation in rats and mice E. The Neurobiology of FSE-induced epilepsy and cognitive deficits: Experimental approaches 16. The pathogenesis of FSE-induced epilepsy: Neuroinflammation and Epigenetics 17. MicroRNAs and Epigenetic processes in FSE-provoked epilepsy 18. HCN channels in human and rodent Epileptogenesis induced by FSE 19. Cognitive problems following eFSE 20. Predicting TLE-like epilepsy - the role of MRI: F. Clinical and Translational Implications of FSE 21. MRI for assessing the impact of FSE and predicting outcomes 22. EEG for assessing the impact of FSE and predicting outcome G. Management of febrile seizures and FSE- past, present and futures 23. Evaluation and Practical Management approaches to simple and complex febrile seizures 24. What do we tell parents of a child with simple or complex febrile seizures? 25. The future of FS, FSE and their epileptogenic and cognitive outcomes

• ISBN: 978-0-323-89932-1
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Fecha Publicación: 01/09/2022
• Nº Volúmenes: 1
• Idioma: Inglés