The Pancreas: An Integrated Textbook of Basic Science, Medicine, and Surgery

The Pancreas: An Integrated Textbook of Basic Science, Medicine, and Surgery

Beger, Hans G.
Warshaw, Andrew L.
Hruban, Ralph H.
Buchler, Markus W.
Lerch, Markus M.
Neoptolemos, John P.
Shimosegawa, Tooru
Whitcomb, David C.

411,74 €(IVA inc.)

This brand new updated edition of the most comprehensive reference book on pancreatic disease details the very latest knowledge on genetics and molecular biological background in terms of anatomy, physiology, pathology, and pathophysiology for all known disorders. Included for the first time, are two brand new sections on the key areas of Autoimmune Pancreatitis and Benign Cystic Neoplasms. In addition, this edition is filled with over 500 high–quality illustrations, line drawings, and radiographs that provide a step–by–step approach to all endoscopic techniques and surgical procedures. Each of these images can be downloaded via an online image bank for use in scientific presentations.  Every existing chapter in The Pancreas: An Integrated Textbook of Basic Science, Medicine and Surgery, 3rd Edition has been thoroughly revised and updated to include the many changes in clinical practice since publication of the current edition. The book includes new guidelines for non–surgical and surgical treatment; new molecular biologic pathways to support clinical decision making in targeted treatment of pancreatic cancer; new minimally invasive surgical approaches for pancreatic diseases; and the latest knowledge of neuroendocrine tumors and periampullary tumors. The most encyclopedic book on the pancreas providing outstanding and clear guidance for the practicing clinician Covers every known pancreatic disorder in detail including its anatomy, physiology, pathology, pathophysiology, diagnosis, and management Completely updated with brand new chapters Over 500 downloadable illustrations An editor and author team of high international repute who present global best–practice The Pancreas: An Integrated Textbook of Basic Science, Medicine and Surgery, 3rd Edition is an important book for gastroenterologists and gastrointestinal surgeons worldwide. INDICE: Contributors xiii .Preface xxix .Abbreviations xxx .About the Companion Website xlii .Section 1 Anatomy of the Pancreas 1 .1 Development of the Pancreas and Related Structures 3Brian Lewis and Junhao Mao .2 Anatomy, Histology, and Fine Structure of the Pancreas 10Daniel S. Longnecker, Fred Gorelick, and Elizabeth D. Thompson .3 Congenital and Inherited Anomalies of the Pancreas 24Martin Zenker and Markus M. Lerch .Section 2 Physiology and Pathophysiology of Pancreatic Functions 41 .4 Physiology of Acinar Cell Secretion 43Ole H. Petersen .5 Physiology of Duct Cell Secretion 56Mei Zeng, Laura Vachel, and Shmuel Muallem .6 Pathophysiology of Experimental Pancreatitis 63Vikas Dudeja, Rajinder Dawra, and Ashok K. Saluja .7 Physiology and Pathophysiology of Function of Sphincter of Oddi 75Savio George Barreto and James Toouli .8 Neurohormonal and Hormonal Control of Pancreatic Secretion 84Chung Owyang .9 Regulation of Pancreatic Protein Synthesis and Growth 95Maria Dolors Sans and John A. Williams .10 Fibrogenesis in the Pancreas: The Role of Stellate Cells 106Minoti V. Apte, Romano C. Pirola, and Jeremy S. Wilson .11 Fibrogenesis of the Pancreas: The Role of Macrophages 117Aida Habtezion .12 Insulo Acinar Relationship 123Keiko Shiratori and Kyoko Shimizu .Section 3 Acute Pancreatitis 133 .13 Epidemiology and Etiology of Alcohol ]Induced Pancreatitis 135Jeremy S. Wilson, Romano C. Pirola, and Minoti V. Apte .14 Epidemiology and Etiology of Acute Biliary Pancreatitis 146Michael G.T. Raraty, Andrea Sheel, and John P. Neoptolemos .15 Genetic Factors in Acute Pancreatitis 158Zachary Zator and Georgios I. Papachristou .16 The Role of the Intestine and Mesenteric Lymph in the Development of Systemic Inflammation and MODS in Severe Acute Pancreatitis 166Alistair B.J. Escott, Anthony R.J. Phillips, and John A. Windsor .17 The Role of Neurogenic Inflammation in Pancreatitis 173Jami L. Saloman, Kathryn M. Albers, and Brian M. Davis .18 Molecular, Biochemical, and Metabolic Abnormalities in Acute Pancreatitis 178Julia Mayerle, Frank Ulrich Weiss, Walter Halangk, and Markus M. Lerch .19 Histopathology of Acute Pancreatitis 193Günter Klöppel .20 Clinical Classification Systems of Acute Pancreatitis 199John A. Windsor and Max S. Petrov .21 Clinical Assessment and Biochemical Markers to Objectify Severity and Prognosis 204Bettina M. Rau and Guido Alsfasser .22 Acute Pancreatitis Associated With Congenital Anomalies 213Christopher R. Schlieve, Andrew L. Warshaw, and Tracy C. Grikscheit .23 Acute Pancreatitis in Children 219Mark E. Lowe and Véronique D. Morinville .24 Acute Pancreatitis Associated With Metabolic Disorders, Infectious Diseases, or Drugs 230Ali A. Aghdassi and Markus M. Lerch .25 Radiologic Diagnosis and Staging of Severe Acute Pancreatitis 238Yoshihisa Tsuji Clinical Course and Medical Treatment of Acute Pancreatitis 251 .26 Conservative Therapy of Acute Pancreatitis: Volume Substitution and Enteral and Parenteral Nutrition 251Timothy B. Gardner .27 ICU Treatment of Severe Acute Pancreatitis 258Scott R. Gunn and David C. Whitcomb .28 Use of Antibiotics in Severe Acute Pancreatitis: Indications and Limitations 265Rainer Isenmann and Mathias Wittau .Interventional and Surgical Management of Acute Pancreatitis 271 .29 Indications for Interventional and Surgical Treatment of Necrotizing Pancreatitis 271Thomas E. Clancy .30 Management of Infected Pancreatic Necroses: An Endoscopic Approach 277Eduardo Rodrigues ]Pinto and Todd H. Baron .31 Minimally Invasive Debridement and Lavage of Necrotizing Pancreatitis 283Rebecca Saunders, Michael G.T. Raraty, Chris Halloran, and John P. Neoptolemos .32 Open Surgical Debridement in Necrotizing Pancreatitis 289Lutz Schneider and Markus W. Büchler .33 Endoscopic Treatment of Biliary Acute Pancreatitis 296Ichiro Yasuda, Shinpei Doi, and Masatoshi Mabuchi .34 Strategies for the Treatment of Pancreatic Pseudocysts and Walled ]Off Necrosis After Acute Pancreatitis: Interventional Endoscopic Approaches 301Georg Beyer, Julia Mayerle, and Markus M. Lerch .35 Strategies for the Treatment of Pancreatic Pseudocysts and Walled ]Off Necrosis After Acute Pancreatitis: Surgical  Treatment 305Naohiro Sata, Masaru Koizumi, and Alan K. Lefor .36 Management of Fluid Collection in Acute Pancreatitis 311Felix Lämmerhirt, Frank Ulrich Weiss, and Markus M. Lerch .37 Management of Pancreatic Fistula in Acute Pancreatitis 316Jörg Kaiser, Thilo Hackert, and Markus W. Büchler .Long–Term Outcome After Treatment of Acute Pancreatitis 323 .38 Long ]Term Outcome After Acute Pancreatitis 323Christin Tjaden and Thilo Hackert .Section 4 Chronic Pancreatitis 331 .39 Molecular Understanding of Chronic Pancreatitis 333John F. Eisses and Sohail Z. Husain .40 Epidemiology and Pathophysiology of Alcoholic Chronic Pancreatitis 342Atsushi Masamune and Tooru Shimosegawa .41 Pain Mechanisms in Chronic Pancreatitis 349Pierluigi di Sebastiano, Tommaso Grottola, and Francesco F. di Mola .42 Natural History of Recurrent Acute and Chronic Pancreatitis 355Rohit Das and Dhiraj Yadav .43 Chronic Pancreatitis with Inflammatory Mass of the Pancreatic Head 365Ulrich F. Wellner and Tobias Keck .44 Early Chronic Pancreatitis 371Tetsuhide Ito, Masayuki Hijioka, and Tooru Shimosegawa .45 Hereditary Chronic Pancreatitis: Molecular Pattern, Clinical Consequences, and Management Principles 374Celeste Shelton and David C. Whitcomb .46 Epidemiology and Pathophysiology of Tropical Chronic Pancreatitis 384Shailesh V. Shrikhande and Savio George Barreto .47 Cystic Fibrosis (CFTR) ]Associated Pancreatic Disease 391Chee Y. Ooi and Aliye Uc .48 Clinical and Laboratory Diagnosis of Chronic Pancreatitis 397Julia Mayerle, Peter Simon, and Markus M. Lerch .49 Evidence of Contrast ]Enhanced CT and MRI/MRCP 406J. Enrique Domínguez ]Muñoz, Roberto García ]Figueiras, and Julio Iglesias ]García .50 Chronic Pancreatitis: Risk Factors in Cancer 417Albert B. Lowenfels and Patrick Maisonneuve .Conservative Treatment of Chronic Pancreatitis 421 .51 Pain Management in Chronic Pancreatitis 421Kai Bachmann, Stephanie Plagemann, Yogesh Kumar Vashist, and Jakob R. Izbicki .52 Medical Treatment of Chronic Pancreatitis: Pancreatic Digestive Enzymes: Lipases, Proteases 426Mark E. Lowe .53 Nutritional Support of Chronic Pancreatitis 429Sinead N. Duggan and Stephen J. O Keefe .54 Medical Therapy for Chronic Pancreatitis: Antioxidants 435Chris E. Forsmark .Strategies for Endoscopic and Surgical Treatment of Chronic Pancreatitis 439 .55 Evidence of Endoscopic and Interventional Treatment of Chronic Pancreatitis and Pseudocysts 439Jörg Schirra, Markus M. Lerch, and Julia Mayerle .56 Indications and Goals of Surgical Treatment 449Ryan T. Groeschl and Michael B. Farnell .57 Pancreatic Duct Drainage Procedure 453Dirk Bausch and Tobias Keck .58 Duodenum ]Preserving Pancreatic Head Resection 458Hans G. Beger, Bertram Poch, Yang Yinmo, and Waldemar Uhl .59 Major Pancreatic Resection 467May C. Tee and Michael B. Farnell .60 Laparoscopic Surgery 479Vernissia Tam, Melissa E. Hogg, and Amer Zureikat .Management of Diabetes and Long–Term Outcome of Chronic Pancreatitis 488 .61 Chronic Pancreatitis: Long ]Term Outcome After Medical and Surgical Treatment 488Volker Aßfalg, Norbert Hüser, and Helmut Friess .62 Management of Pancreatic Diabetes Secondary to Chronic Pancreatitis 495Keiko Shiratori .Section 5 Autoimmune Pancreatitis 503 .63 Epidemiology of Autoimmune Pancreatitis 505Terumi Kamisawa and Tooru Shimosegawa .64 Pathogenesis of Autoimmune Pancreatitis 510Yoh Zen .65 Histology of Autoimmune Pancreatitis 516Rajib Gupta and Vikram Deshpande .66 Clinical Manifestation of Type 1 Autoimmune Pancreatitis 520Tooru Shimosegawa, Morihisa Hirota, and Atsushi Kanno .67 Clinical Manifestations of Type 2 Autoimmune Pancreatitis 534Emma L. Culver and George Webster .68 Laboratory Diagnosis of Autoimmune Pancreatitis 539J. ]Matthias Löhr, Pia Maier, and Stephan L. Haas .69 What is the Evidence Measuring Immune Markers 544Shigeyuki Kawa .70 Imaging Diagnosis of Autoimmune Pancreatitis 550Kazuichi Okazaki, Tsukasa Ikeura, Kazushige Uchida, and Makoto Takaoka .71 Medical Management of Autoimmune Pancreatitis 555Shounak Majumder and Suresh T. Chari .Long–Term Outcome of Management of Autoimmune Pancreatitis 560 .72 Long ]Term Outcome After Treatment of Autoimmune Pancreatitis 560Luca Frulloni and Nicolò de Pretis .Section 6 Neoplastic Tumors of the Exocrine Tissue: Benign Cystic Neoplasms of the Pancreas 565 .73 Epidemiology of Cystic Neoplasms of the Pancreas 567Saurabh Mukewar and Suresh T. Chari .74 Histologic Classification and Staging of Cystic Neoplasms 573Noriyoshi Fukushima and Giuseppe Zamboni .75 Molecular Mechanisms of Cystic Neoplasia 580Nickolas Papadopoulos and Ralph H. Hruban .76 Clinical Presentation of Cystic Neoplasms 589Susumu Hijioka, Kazuo Hara, Nobumasa Mizuno, Nozomi Okuno, and Kenji Yamao .77 Evaluation of Cystic Lesions Using EUS, MRI, and CT 593Anne Marie Lennon and Hiroyuki Maguchi .78 Cytologic Evaluation of Cystic Neoplasms 603Martha Bishop Pitman .79 Natural History of Cystic Neoplasms: IPMN, MCN, SCN, and SPN 611Anna ]Katharina Stadler, Thilo Hackert, Stefan Fritz, and Markus W. Büchler .80 Surveillance or Surgical Treatment in Asymptomatic Cystic Neoplasms 618Klaus Sahora and Carlos Fernández ] del Castillo .Local and Standard Surgical Treatment of Cystic Neoplasms 622 .81 Duodenum ]Preserving Partial or Total Pancreatic Head Resection 622Hans G. Beger and Bertram Poch .82 Pancreatic Middle Segment Resection 627Calogero Iacono .83 The Indications For and Limitations of Tumor Enucleation 632Rosalie A. Carr, C. Max Schmidt, and Henry A. Pitt .84 Standard Surgical Management of IPMN, MCN, SPN, and SCN Lesions: Open Approach 641Miral Sadaria Grandhi, Barish H. Edil, and Richard D. Schulick .85 Surgical Treatment of Cystic Neoplasms: Laparoscopic Approach 649Richard A. Burkhart, Christopher L. Wolfgang, Markus W. Büchler, and Thilo Hackert .86 Management of Recurrence of Cystic Neoplasms 655Zhi Ven Fong, Christopher L. Wolfgang, and Keith D. Lillemoe .Long–Term Outcome of Management of Cystic Neoplasms 660 .87 Long ]Term Outcome After Observation and Surgical Treatment: What is the Evidence? 660Giovanni Marchegiani, Giuseppe Malleo, and Claudio Bassi .Section 7 Neoplastic Tumors of Exocrine Tissue: Pancreatic Cancer 665 .88 Epidemiology of Pancreatic Cancer 667Evelina Mocci and Alison P. Klein .89 Smoking, a Risk for Pancreatic Cancer: Experimental and Clinical Data 673Uwe A. Wittel, Bradley R. Hall, and Surinder K. Batra .90 Molecular Understanding of Development of Ductal Pancreatic Cancer 679Laura D. Wood and Ralph H. Hruban .91 Familial Pancreatic Cancer 688Alison P. Klein .92 Pathology of Exocrine Pancreatic Tumors 693Meredith E. Pittman and Ralph H. Hruban .93 Pancreatic Cancer: Precancerous Lesions 705Michaël Noë, Lodewijk A.A. Brosens, and Johan Offerhaus .94 Clinical History and Risk Factors of Pancreatic Cancer 717Norbert Hüser, Volker Aßfalg, and Helmut Friess .95 Pancreatic Cancer Within the Uncinate Process: Radiologic and Clinical Characteristics 724Sebastian Holländer and Dieter Birk .96 The Role of EUS in the Diagnosis and Differential Diagnosis of Neoplastic Lesions 728Susumu Hijioka, Kazuo Hara, Nobumasa Mizuno, Nozomi Okuno, and Kenji Yamao .97 Radiologic Diagnosis of Pancreatic Cancer: CT, MRI 733Siva P. Raman and Elliot K. Fishman .98 Screening of Patients with Hereditary Pancreatic Cancer 745Michael Goggins .99 The Role of PET in Diagnosis of Pancreatic Cancer and Cancer Recurrence 755Norbert Hüser, Volker Aßfalg, Isabel Rauscher, and Helmut Friess .100 Tumor Markers in Pancreatic Malignancies 762Shin Hamada, Atsushi Masamune, and Tooru Shimosegawa .101 The Role of Laparoscopy and Peritoneal Cytology in the Management of Pancreatic Cancer 766Kyoichi Takaori and Shinji Uemoto .102 Clinical Assessment and Staging of Advanced Pancreatic Cancer 770Jennifer LaFemina, Ann K. Friedrich, and Giles F. Whalen .Surgical Treatment of Pancreatic Cancer 776 .103 Pancreatic Cancer: Indications for Resection 776Akimasa Nakao .104 Pancreaticoduodenectomy for Pancreatic Cancer, Short ] and Long ]Term Outcomes After Kausch Whipple and Pylorus ]Preserving Resection 783Jin He and John L. Cameron .105 Left Pancreatectomy for Body and Tail Cancer 790Georgios Gemenetzis and Christopher L. Wolfgang .106 Total Pancreatectomy: Indications and Limitations 797Seiko Hirono and Hiroki Yamaue .107 Laparoscopic and Robotic Resection for Pancreatic Cancer 804Deepa Magge, Herbert J. Zeh, and Melissa E. Hogg .108 Extended Radical Surgery for Pancreatic Cancer 814Thilo Hackert, Alexis Ulrich, and Markus W. Büchler .109 Palliative Pancreatoduodenectomy: Benefits and Limitations 823Christoph W. Michalski, Max Heckler, Mert Erkan, and Markus W. Büchler .110 Bypass Surgery for Advanced Pancreatic Cancer 828Jürgen Weitz, Thomas Pausch, Christoph W. Michalski, and Thilo Hackert .Nonsurgical Palliation of Pancreatic Cancer 835 .111 Endoscopic and Interventional Palliation of Pancreatic Cancer 835Takao Itoi .Medical Treatment of Pancreatic Cancer 842 .112 Neoadjuvant Treatment of Pancreatic Cancer: Downstaging Results 842Robert A. Wolff and Gauri Varadhachary .113 Adjuvant Chemotherapy in Pancreatic Cancer 847Robert P. Jones, Paula Ghaneh, and John P. Neoptolemos .114 Immunotherapy for Pancreatic Cancer 856Adrian G. Murphy, Elizabeth M. Jaffee, and Lei Zheng .115 Targeted Therapies for Pancreatic Cancer 865Vincent Bernard and Anirban Maitra .116 Palliative Chemotherapy for Advanced Pancreatic Cancer: Survival Benefit and Side Effects of Treatment 872Olusola O. Faluyi, Madhuchanda Chatterjee, and Daniel H. Palmer .117 Management of Pain in Pancreatic Cancer 879Michael Erdek, Indy Wilkinson, and Zackary E. Boomsaad .118 Role of Radio and Proton Beam Therapy for Pancreatic Cancer 886Amol K. Narang, Lauren M. Rosati, Michael D. Chuong, and Joseph M. Herman .119 Management of Cancer Recurrence 895Oliver Strobel and Markus W. Büchler .Long–Term Outcome After Treatment of Pancreatic Cancer 906 .120 Survival and Late Morbidity After Resection of Pancreatic Cancer 906Avinoam Nevler, Charles J. Yeo, and Jordan M. Winter .Section 8 Neoplastic Tumors of the Endocrine Pancreas: Neuroendocrine Tumors of the Pancreas 919 .121 Epidemiology and Classification of Neuroendocrine Tumors of the Pancreas 921J.J. Mukherjee, Kok ]Onn Lee, and Gregory Kaltsas .122 Pathology of Neuroendocrine Neoplasms 930Atsuko Kasajima and Hironobu Sasano .123 Molecular Genetics of Neuroendocrine Tumors 937Nickolas Papadopoulos and Ralph H. Hruban .124 Clinical Manifestation of Endocrine Tumors of the Pancreas 947Ken Kawabe and Tetsuhide Ito .125 Evidence of Hormonal, Laboratory, Biochemical, and Instrumental Diagnostics of Neuroendocrine Tumors of the Pancreas 953Kok ]Onn Lee, Gregory Kaltsas, and J.J. Mukherjee .126 Pancreatic Neuroendocrine Tumors in Multiple Neoplasia Syndromes 961Anja Rinke and Thomas Matthias Gress .127 Nonfunctioning Pancreatic Neuroendocrine Tumors: Diagnosis and Management Principles 967Takao Ohtsuka, Hideyo Kimura, and Masafumi Nakamura .128 Medical and Nucleotide Treatment of Neuroendocrine Tumors of the Pancreas 972Gregory Kaltsas, J.J. Mukherjee, and Kok ]Onn Lee .129 Interventional Radiology in the Treatment of Pancreatic Neuroendocrine Tumors 979Takao Ohtsuka, Hideyo Kimura, and Masafumi Nakamura .Surgical Management of Endocrine Tumors of the Pancreas 982 .130 Surgical Treatment of Endocrine Tumors: Enucleation 982Henning Dralle, Phuong Nguyen Thanh, and Andreas Machens .131 Local Treatment of Endocrine Tumors: Duodenum ]Preserving Partial or Total Pancreatic Head Resection and Pancreatic Middle ]Segment Resection 989Hans G. Beger and Wataru Kimura .132 Surgical Treatment of Endocrine Tumors: Major Oncologic Resection 994Henning Dralle, Phuong Nguyen Thanh, and Andreas Machens .133 Management of Insulinoma 1002Keijiro Ueda, Linkaku Lee, and Tetsuhide Ito .134 Evidence of Medical and Surgical Treatment of Gastrinoma 1009Ryuichiro Doi .135 Rare Neuroendocrine Tumors of the Pancreas: Management and Evidence of Surgical Treatment 1013Ryuichiro Doi .136 Treatment of Neuroendocrine Tumors of the Pancreas and Biliary Tract 1019Andrea Frilling, Ashley K. Clift, and Vito Cincinnati .Long–Term Outcome After Treatment of Neuroendocrine Tumors of the Pancreas 1029 .137 Long ]Term Outcome After Treatment of Endocrine Tumors 1029Andreas Machens and Henning Dralle .Section 9 Periampullary Cancers and Tumors Other Than Pancreatic Cancer 1035 .138 Periampullary Cancer: Clinical Presentation and Diagnostic Strategies 1037Amanda B. Cooper and Keith D. Lillemoe .139 Histology and Genetics of Cancer of the Papilla, Distal Common Bile Duct, and Duodenum 1047Yue Xue, Michelle D. Reid, and N. Volkan Adsay .140 Adenoma and Adenocarcinoma of the Ampulla of Vater: Diagnosis and Management 1058Omer Basar and William R. Brugge .141 Endoscopic Treatment of Adenomas of the Ampulla of Vater: Techniques, Results, Benefits, and Limitations 1068Natsuyo Yamamoto, Hiroyuki Isayama, and Kazuhiko Koike .142 Surgical Treatment of Adenoma and Cancer of Papilla of Vater 1074Hans G. Beger, Bertram Poch, and Bettina M. Rau .143 Surgical Treatment of Duodenal Cancer 1081Fuyuhiko Motoi and Michiaki Unno .144 Surgical Treatment of Distal Cholangiocarcinoma 1083Yukihiro Yokoyama, Tomoki Ebata, and Masato Nagino .145 Adjuvant and Palliative Chemotherapy of Periampullary Cancers 1089Eyas Mohamed, Paula Ghaneh, and John P. Neoptolemos .Long–Term Survival After Tumor Resection 1097 .146 Long ]Term Survival After Resection of Periampullary Cancer 1097Masayuki Ohtsuka and Masaru Miyazaki .Section 10 Transplantation of the Pancreas 1107 .147 Transplantation of Pancreatic Islets 1109Bernhard J. Hering and Melena D. Bellin .148 Transplantation of the Pancreas 1121Hans W. Sollinger and Dixon B. Kaufman .Index 1129

  • ISBN: 978-1-119-18839-1
  • Editorial: Wiley–Blackwell
  • Encuadernacion: Cartoné
  • Páginas: 1216
  • Fecha Publicación: 18/04/2018
  • Nº Volúmenes: 1
  • Idioma: Inglés