Structure and function of the neural cell adhesion molecule NCAM

This book contains review articles that produce a snapshot of recent developments in the field of the neural cell adhesion molecule NCAM. The chapters are grouped into sections reflecting various aspects of NCAM structure and function. The themes cover the structural basis of cell adhesion mediated by NCAM andNCAM interaction partners, NCAM-mediated signaling determinants of NCAM function under physiological conditions and in disease, and the therapeutic potential of NCAM mimetics. Introduction to current knowledge of extracellular and intracellular NCAM ligands and the structural basis of NCAM interactions with the fibroblast growth factor (FGF) receptor Chapters are grouped into sections reflecting various aspects of NCAM structure and function, making for a straightforward approach to NCAM Explores new therapeutic potential of NCAM mimetics INDICE: Structure and Ligands of NCAM.Structural Biology of NCAM.Extracellular Protein Interactions Mediated by NCAM: Heterophilic Interactions between NCAM and Cell Adhesion Molecules, Extracellular Matrix Proteins, and Viruses.Intracellular Ligands of NCAM.NCAM and the FGF receptor.The Role of ATP in the Regulation of NCAM Function.- NCAM and Polysialic Acid.Polysialylation of NCAM.Structural Basis for the Polysialylation of NCAM.The Role of PSA-NCAM in Adult Neurogenesis.Use of PSA-NCAM in Repair of the Central Nervous System.- NCAM-mediated Signal Transduction.Signaling Pathways Involved in NCAM-induced Neurite Outgrowth.Role of Growth-Associated Protein GAP-43 in NCAM-mediated NeuriteOutgrowth.NCAM and Lipid Rafts.NCAM and Epidermal Growth Factor Receptor: Signaling Crosstalk.- NCAM Metabolism.Biosynthesis of NCAM.Soluble NCAM.- NCAM, Synapses, Emotions, and Memory.Role of NCAM in Spine Dynamics and Synaptogenesis.NCAM in Long-term Potentiation and Learning.Role of NCAM in Emotion and Learning.- NCAM in Disease.NCAM in Neuropsychiatric and Neurodegenerative Disorders.NCAM in Cancer: Expression and Mechanisms.- Pharmacology of NCAM: NCAM Mimetics.NCAM Mimetic Peptides: An Update.Synthetic NCAM-derived Ligands of the FGFreceptor.Dendritic Spine and Synapse Morphological Alterations Induced by an NCAM Mimetic.- Orthologs and Paralogs of NCAM.Fasciclin II: The NCAM Ortholog in Drosophila melanogaster.The Neural Cell Adhesion Molecule NCAM2/OCAM/RNCAM:A Close Relative of NCAM.- Conclusion.Honoring Dr. Elisabeth Bock.

• ISBN: 978-1-4419-1169-8
• Editorial: Springer
• Encuadernacion: Cartoné
• Páginas: 500
• Fecha Publicación: 01/11/2009
• Nº Volúmenes: 1
• Idioma: Inglés