The physical basis of biochemistry: the foundations of molecular biophysics

Biological chemistry has changed since the completion of the human genome project. There is a renewed interest and market for individuals trained in biophysical chemistry and molecular biophysics. The Physical Basis of Biochemistry, Second Edition , emphasizes the interdisciplinary nature of biophysical chemistry by incorporating the quantitative perspective of the physical sciences without sacrificing the complexity and diversity of the biological systems, applies physical and chemical principles to the understanding of the biology of cells and explores the explosive developments in the area of genomics, and in turn, proteomics, bioinformatics, and computational and visualization technologies that have occurred in the past seven years. The book features problem sets and examples, clear illustrations, and extensive appendixes that provide additional information on related topics in mathematics, physics and chemistry. Grounds students in the basic principles of biochemistry and molecular biophysics Delves into the explosive developments in the area of genomics, and in turn, proteomics, bioinformatics, and computational and visualization technologies Emphasizes the interdisciplinary nature of biophysical chemistry Contains numerous problem sets and examples, and clear illustrations INDICE: Preface.- Introduction.Philosophy and practice of biophysical study.Overview of the biological system under study – descriptive models.Physical thoughts, biological systems - the application of modeling principles to understanding biological systems.Probability and statistics.- Physical principles: energy, the prime observable.Biophysical forces in molecular systems.An introduction to quantum mechanics.Chemical principles.Measuring the energy of a system: energetics and the first law of thermodynamics.Entropy and the second law of thermodynamics.Which way did that system go? The gibbs free energy.The thermodynamics of phase equilibria.- Water: a unique structure, a unique solvent.Ion-solvent interactions.Ion-ion interactions.Lipids in aqueous solution.Macromolecules in solution.Molecular modeling - mapping biochemical state space.The electrified interphase.- Transport and kinetics: processes not at equilibrium.Flow in a chemical potential field: diffusion.Flow in an electrical field: conduction.Forces across membranes.Kinetics - chemical kinetics.Bioelectrochemistry – charge transfer in biological systems.- Separation and characterization of biomolecules based on macroscopic properties.Determining structure by molecular interactions with photons: electronic spectroscopy.Determining structure by molecular interactions with photons: scattering phenomena.Analysis of structure – microscopy.Epilogue.Physical constants.- Appendix A review of mathematical methods.Appendix B quantum electrodynamics.Appendix C the pre-socratic roots of modern science.Appendix D the poisson function.Appendix E assumptions of a kinetic theory of ideal gas behavior.Appendix F determination of a field from the potential.Appendix G geometric optics.Appendix H the compton effect.Appendix I hamilton's principle of least action/fermat's principle of least time.Appendix J energy of interaction between ions.Appendix K derivation of the statement, qrev > qirrev.Appendix L derivation of the clausius-clapeyron equation.Appendix M derivation of the van't hoff equation for osmotic pressure.AppendixN pseudoforces.Appendix O work of charging and discharging a rigid sphere.Appendix P review of electrical circuits.Appendix Q Fermi's golden rule.Appendix R adiabatic vs non-adiabatic processes.

• ISBN: 978-1-4419-6323-9
• Editorial: Springer
• Encuadernacion: Cartoné
• Páginas: 600
• Fecha Publicación: 29/08/2010
• Nº Volúmenes: 1
• Idioma: Inglés