Acinetobacter biology and pathogenesis

There is currently increasing interest concerning the biology and disease caused by Acinetobacter species. Such interest, however, developed relatively slowly because of the necessity to clarify the confusing taxonomy of these organisms. Much work was needed to identify various species as members of this genus, to recognize their epidemiologic profile, their pathogenic role and their increasing importance as multi-antibiotic resistant organisms. In recent years improvement of genetic approaches, recognition of plasmids, integrons and chromosomal sources of resistance mechanisms aroused interest of on the role of Acinetobacters in disease by many microbiologists and clinicians, especially internists and infectious disease specialists. In this regard, physicians are frequently confronted with extremely difficult therapeutic approaches for treatment and prevention of severe nosocomial infections due to multi antibiotic resistant Acinetobacter. Will cover for the first time in one volume all aspects ofthe research, clinical aspects, laboratory diagnosis, genetics, pathogenicity, epidemiology, prevention and control of acinetobacter INDICE: History and Importance of Acinetobacter spp.- Overview of the Microbial Characteristics, Taxonomy and Epidemiology of Acinetobacter.- Genome Organization, Mutation and Gene Expression in Acinetobacter.- Molecular Epidemiology of Acinetobacter Species.- Typing Acinetobacter Strains: Application and Methods.- Efflux Pumps in Acinetobacter baumannii.- Acinetobacter baumannii: Mechanisms of Resistance, Multiple ß-Lactamases.- Virulence Mechanisms of Acinetobacter.- Clinical Experience, Nosocomial Infections, Community Acquired Acinetobacter Infections.- Experimental Models of Acinetobacter Infection.- Antimicrobial Resistance and Therapeutic Alternatives.- US Army Experience with Acinetobacter in Operation Iraqi Freedom.- Perspectives.

• ISBN: 978-0-387-77943-0
• Editorial: Springer
• Encuadernacion: Cartoné
• Páginas: 225
• Fecha Publicación: 01/06/2008
• Nº Volúmenes: 1
• Idioma: Inglés