Domino Reactions in Drug Discovery presents a concise selection of domino reactions employed in routes for the synthesis of pharmaceuticals, agrochemicals and the design of new drug candidates. These versatile reactions play an important and integral part in both the aesthetic appeal and functional aspects of strategic drug discovery, lending enhanced efficiency and synthetic versatility to pharmaceutical drug design. Due to their atom economy, these reactions are increasingly popular in the development of complex scaffolds and multifunctional derivatives aimed at the synthesis of new chemical entities and approved APIs across diverse therapeutic classes, including antidiabetics [DPP4 inhibitors], anticancer therapies and HIV integrase inhibitors. Features illustrated schemes with mechanisms, procedures and resultsIncludes a compendium of Domino Name Reactions for drugsProvides a concise, comprehensive coverage of domino reactions in drug discovery, with a focus on sustainable practices INDICE: 1. Introduction: Origin, Genesis and Relevance of Domino Reactions 2. Asymmetric Domino Reactions 3. Metal-Catalyzed Domino Reactions 4. Enzymatic Domino Processes 5. Heterocyclic Domino Reactions 6. Domino Reactions in the Synthesis of Target Molecules 7. Domino Name Reactions 8. Enzyme-catalysed Domino Reactions in Pharmaceutical Perspective 9. Case Studies of Coupled Name Reactions 10. Conventional route of synthesis as per product patent of drug 11. Comparison between DNR & conventional RoS [Route of Synthesis] 12. Applications of Domino Reactions in Chiral Drug Design 13. References & Suggested Readings: Literature Review including Patents
- ISBN: 978-0-12-819374-7
- Editorial: Elsevier
- Encuadernacion: Rústica
- Páginas: 315
- Fecha Publicación: 01/10/2020
- Nº Volúmenes: 1
- Idioma: Inglés