Chromatin Readers in Health and Disease, Volume 32, a new release in the Translational Epigenetics series, gathers and makes actionable our current understanding of how chromatin readers regulate access to genetic information, and how their aberrant regulation can contribute to human pathologies. Chromatin readers discussed include 14-3-3 Dinshaw, ADD, Ankyrin, BAH, BET, BIR, BRCT, bromodomains and Kac readers, chromodomains and chromobarrel readers, citrullination readers, macrodomains and poly-ADP-ribose readers, MBT, PHD and double PHD, PWWP, SUMO (H4K12) readers, Tudor and TTD, UDR and ubiquitin, WD40, YEATS (crotonyl reader)?, MBD, SRA, and Methyl-RNA readers.In the book, more than a dozen leaders in the field examine a range of protein readers, their relationship to human disease, and the early therapeutics that act as chromatin signaling factors to treat cancers and Huntington's disease, among other disorders. Enables researchers and clinicians to understand chromatin signaling mechanisms that regulate gene expression through chromatin readers Highlights the role of chromatin readers in a variety of human pathologies, as well as early therapeutics that act on chromatin signaling Includes chapter contributions from international leaders in the field INDICE: 1. ADD domains - a regulatory hub in chromatin biology and disease2. BAH3. BIR4. BRCT Domains as Chromatin Readers: Structure, Function, and Clinical Implications5. The bromodomain acyl-lysine readers in human health and disease6. Chromodomains7. CW-type zinc fingers8. Macrodomains and PAR readers9. MBT10. PHD and double PHD finger11. PWWP12. SPIN repeats and human pathologies13. Tudor and TTD14. UDR and Ubiquitin15. WD4016. YEATS17. Multivalent readers and interplay among different readers18. DNA Methylation and Reader- or Writer-Proteins: Differentiation and Disease19. R-loops readers20. CUT&RUN and CUT&Tag: Low-input methods for genome-wide mapping of chromatin proteins
- ISBN: 978-0-12-823376-4
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 416
- Fecha Publicación: 01/10/2022
- Nº Volúmenes: 1
- Idioma: Inglés