Basic Principles of Drug Discovery and Development explains that identifying a new drug in the modern era is a multifaceted endeavor that requires a multidisciplinary team approach. It also describes enabling technologies such as high throughput screening, structure based drug design, molecular modeling, pharmaceutical profiling, and translational medicine that have become critical to the successful development of marketable therapeutics. This book introduces the fundamental principles of drug discovery and development, beginning with an historical overview of drug discovery. It then educates readers about important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles in pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process. It is designed to enable a new scientist to rapidly understand the key fundamentals of drug discovery including pharmacokinetics, toxicology, and intellectual property, to fill knowledge gaps that could lead to communication issues. Clearly explains the complete drug discovery process from obtaining a lead to testing the bioactivity, to producing the drug and protecting the intellectual propertyDesigned for everyone learning about or thinking of entering the drug discovery space (and transitioning from academia to industry or from another industry to pharma)Simply presents and describes how the pharmaceutical industry works INDICE: An overview of drug discovery process A history of drug discovery: From early days to modern times Classical targets in drug discovery In Vitro Screening Systems Medicinal Chemistry in Drug Discovery Pharmacokinetics: Basic ADMET Principles Animal Models of Disease States Safety and Toxicology Basics of Clinical Trials Translational and Experimental Medicine in Drug Discovery Organizational Structures of Biotech Operations Intellectual Property and Patents in Drug Discovery Case studies in drug discovery
- ISBN: 978-0-12-411508-8
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 448
- Fecha Publicación: 13/12/2014
- Nº Volúmenes: 1
- Idioma: Inglés