Cancer chemotherapy can be traced back to the 1940’s and since then the worldhas witnessed the discovery and the important application of several new drugs. The successes of combination chemotherapy suggested that all cancers can betreated provided that the correct combination of drugs at the correct doses and correct intervals are established. However, with time, tumor cells develop mechanisms of resistance to apoptosis and no longer respond to the majority ofcytotoxic therapies. Sensitization of Cancer Cells for Chemo/Immuno/Radio-therapy, edited by Benjamin Bonavida, reviews novel approaches developed to reverse tumor cell resistance to chemo/immuno/radio-therapy and the use of various sensitizing agents in combination with various cytotoxics. Such sensitizing agents target gene products that regulate resistance and therefore identify novel targets for drug development. The first volume to compile studies on tumor cell sensitization Useful for students, scientists, clinicians and pharmaceutical companies INDICE: From the contents Sensitization of epithelial cancer cells with human monoclonal antibodies.- Targeting the transferrin receptor to overcome resistance to anti-cancer agents.- Chemo-immunosensitization of resistant B-NHL as a result of rituximab (anti CD20 mAb)-mediated inhibition of cell survival signaling pathways.- Agents that regulate DR5 and sensitivity to TRAIL.- Proteasome inhibition: Potential for sensitization of immune effector mechanisms in cancer.- Angiogenesis inhibitors as chemosensitizing agents for the treatment of metastatic disease.- Targeting survival cascades induced by activation of Ras/Raf/MEK/ERK and P13K/Akt pathways to sensitize cancer cells to therapy.- Histone deacetylase inhibitors and anti-cancer activity.- Eicosanoids and resistance of cancer cells to chemotherapeutic agents.- The RKIP and STAT3 axis in cancer chemotherapy: opposites attract.
- ISBN: 978-1-934115-29-9
- Editorial: Humana
- Encuadernacion: Cartoné
- Páginas: 480
- Fecha Publicación: 01/08/2008
- Nº Volúmenes: 1
- Idioma: Inglés