Handbook of in vivo Magnetic Resonance Spectroscopy (MRS)

This handbook covers the entire field of magnetic Resonance Spectroscopy (MRS), a unique method that allows the non–invasive identification, quantification and spatial mapping of metabolites in living organisms including animal models and patients. Comprised of three parts: Methodology covers basic MRS theory, methodology for acquiring, quantifying spectra, and spatially localizing spectra, and equipment essentials, as well as vital ancillary issues such as motion suppression and physiological monitoring. Applications focuses on MRS applications, both in animal models of disease and in human studies of normal physiology and disease, including cancer, neurological disease, cardiac and muscle metabolism, and obesity. Reference includes useful appendices and look up tables of relative MRS signal–to–noise ratios, typical tissue concentrations, structures of common metabolites, and useful formulae. INDICE: 1 Basics of NMR .2 Magnetic Resonance Spectroscopy Instrumentation .3 Detection coils for MRS .4 A Practical Guide to in–vivo MRS .5 Adiabatic Excitation Pulses for MRS .6 Localized MRS employing radiofrequency field (B1) gradients .7 Single Voxel MRS .8 Chemical shift imaging with phase– and sensitivity–encoding .9 Spatial Encoding and Decoding with Prior Knowledge from MRI and Spatio–Spectral Correlation .10 Accurate Localized Spectroscopy from Anatomically Matched Regions with Optimal Spatial Response Function .11 Accelerated Spatially–Encoded MRS of Arbitrarily–Shaped Compartments Using Linear Algebraic Modeling .12 High–Speed Spatial–Spectral Encoding with Echo–Planar and Spiral Spectroscopic Imaging .13 Direct Water––Fat Imaging Methods: Chemical Shift–Selective and Chemical Shift–Encoded MRI .14 Physiological maintenance in animal experiments .15 Physiological maintenance in MRI and MRS of large animals .16 Physiological Monitoring in human MRS .17 Physiologic Motion: Dealing with Cardiac, Respiratory and Other Sporadic Motion in MRS .18 Quantifying Spectra in the Frequency Domain .19 Quantifying Spectra in the Time Domain .20 Advanced spectral quantification: parameter handling, non–parametric pattern modeling and multi–dimensional fitting .21 1H–NMR Chemical Shifts and Coupling Constants for Brain Metabolites .22 Pattern Recognition Analysis of MR Spectra .23 Quantifying Metabolite Ratios and Concentrations by 1H MRS .24 Quantifying Metabolite Ratios and Concentrations by Non–1H MRS .25 Measuring intra– and extra–cellular pH by MRS .26 Temperature Monitoring Using Chemical Shift .27 Diffusion–Weighted MRS .28 Measuring biochemical reaction rates in vivo with magnetization transfer .29 Proton Chemical Exchange Saturation Transfer MRS and MRI .30 Two–Dimensional NMR Spectroscopy Plus Spatial Encoding .31 Spectral editing .32 Multiple quantum MRS .33 Hyperpolarization Methods for MRS .34 Pulse sequences for hyperpolarized MRS .35 MRS of Perfused Cells, Tissues and Organs .36 Metabolism and Metabolomics by MRS .37 In Vivo 19F MRS .38 13C MRS in Human Tissue .39 Hyperpolarized 13C MRI and MRS Studies .40 Integrating 13C Isotopomer Methods with Hyperpolarization for a Comprehensive Picture of Metabolism .41 Muscle studies by 1H MRS .42 Muscle Studies by 31P MRS .43 Measuring Intracellular Oxygenation with Myoglobin 1H MRS .44 Body Fat MRS .45 In Vivo MRS of Lipids in Adipose Tissue, Bone Marrow, and Liver .46 Assessing Fatty Liver with MRS .47 MRS Studies of Muscle and Heart in Obesity and Diabetes .48 Studying Cardiac Lipids in Obese and Diabetic patients by 1H MRS .49 Cardiac MRS Studies in Rodents and Other Animals .50 Assessing Cardiac Transplant Viability with MRS .51 MRS in the Failing Heart: from Mice to Humans .52 MRS studies of Creatine Kinase metabolism in human heart .53 Studying Aging, Dementia, Trauma, Infection, and Developmental Disorders of the Brain with 1H MRS .54 Studying Stroke and Cerebral Ischemia by 1H MRS .55 31P MRS in Psychiatric Disorders .56 The significance of N–Acetyl Aspartate in Human Brain MRS .57 MRS in Brain Cancer .58 MRS in Breast Cancer .59 MRS in Prostate Cancer .60 Clinical Trials of MRS Methods .61 Clinical Trials that Utilize MRS as a Biomarker .62 Properties of NMR–visible isotopes and their biological content in human tissue .63 Concentration ranges of common metabolites detected by MRS in healthy human tissue .64 Peak Assignments for Some Common Metabolites .65 Biochemical reactions and molecular structures of common MRS metabolites .66 Some standard formulae used in MRS .67 Common MRS Artefacts .68 In Vivo Spectra with Peak Assignments

• ISBN: 978-1-118-99766-6
• Editorial: Wiley–Blackwell
• Encuadernacion: Cartoné
• Páginas: 880
• Fecha Publicación: 16/12/2016
• Nº Volúmenes: 1
• Idioma: Inglés