Applications of toxicogenomics in safety evaluation and risk assessment

This book provides a timely overview of toxicogenomics, with special emphasison the practical applications of this technology to the risk assessment process. Introductory sections are followed by a series of chapters highlighting practical and systematic applications of toxicogenomics in informing the risk assessment process including the areas of mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology. The book concludes with approaches for the integration of this technology insafety evaluation studies, and an outlook on how toxicogenomics and complementary technologies can reframe the current risk assessment paradigm. INDICE: Chapter 1: Toxicology, 'Omics' Technologies, and Toxicogenomics: APrimer. Chapter 2: Introduction to Human Health Risk Assessment. Chapter 3: Practical Considerations for the Application of Toxicogenomics to Risk Assessment - Early Experience, Current Drivers, and a Path Forward. Chapter 4: Approaches and Practical Considerations for the Analysis of Toxicogenomics Data. Chapter 5: Genomics in identifying mutagenic mode of action in carcinogenesis. Chapter 6: Application of Genomics for Predicting and Understanding the Mode of Action for Non-Genotoxic Carcinogens. Chapter 7: Genomics in characterizing endocrine toxicity. Chapter 8: Studying Organ Specific Toxicity Using Gene Expression Profiling. Chapter 9: Toxicogenomic Studies in Human Populations. Chapter10: Toxicogenomics Applied to Ecological Risk Assessment. Chapter 11: Analysis of Transcriptomic Dose Response Data for Toxicology and Risk Assessment. Chapter 12: Toxicogenomics as a Tool for Validating Animal to Human Extrapolations in Chemical Risk Assessment: Concepts, Applications and Challenges. Chapter 13: Toxicogenomics and animal alternatives. Chapter 14: Toxicogenomics and theRegulatory Framework. Chapter 15: Standardization of gene expression information for the safety evaluation - Activities in Japan. Chapter 16: Applying Transcriptional Profiling in Drug Safety Evaluation. Chapter 17: Reframing the Risk Assessment Paradigm: Towards a Systems Biology Approach.

• ISBN: 978-0-470-44982-0
• Editorial: John Wiley & Sons
• Encuadernacion: Cartoné
• Páginas: 380
• Fecha Publicación: 08/04/2011
• Nº Volúmenes: 1
• Idioma: Inglés