Trace quantitative analysis by mass spectrometry

Quantitative Chemical Analysis by Mass Spectrometry provides a serious introduction to the subject of mass spectrometry, providing the reader with the tools and information to be well prepared to perform such demanding work in a real-life laboratory. This essential tool bridges several subjects and many disciplines including pharmaceutical, environmental and biomedical analysis that areutilizing mass spectrometry. INDICE: PREFACE Chapter 1: MEASUREMENT, DIMENSIONS AND UNITS 1.1 INTRODUCTION 1.2 The International System of Units (SI) Mass-to-charge ratio in mass spectrometry 1.4 ACHIEVAABLE PRECISION IN MEASUREMENT OF SI BASE QUANTITIES 1.5 MOLECULAR MASS LIMIT FOR TRACE QUANTITATION BY MASS SPECTROMETRY Chapter 2: TOOLS OF THE TRADE I. THE CLASSICAL TOOLS 2.1 Introduction 2.2 Calibration Standards 2.3 The Analytical Balance 2.4 Measurement and Dispensing of Volume 2.5 Preparation of Solutions for Mass Spectrometer Calibration 2.6INTRODUCTION TO CALIBRATION METHODS FOR QUANTITATIVE ANALYSIS BY CHROMATOGRAPHY Chapter 3: TOOLS OF THE TRADE II. THEORY OF CHROMATOGRAPHY 3.1 Introduction 3.2 General Principles OF Chemical Separations 3.3 SUMMARY OF IMPORTANT CONCEPTS 3.4 Plate Theory of Chromatography 3.5 Non-Equilibrium Effects in Chromatography: THE Van Deemter Equation 3.6 Gradient Elution 3.7 Capillary Electrophoresis and Capillary Chapter 4: TOOLS OF THE TRADE III. SEPARATION PRACTICALITIES 4.1 Introduction 4.2 The Analyte and the Matrix 4.3 Extraction and Cleanup Methods 4.4 Chromatographic practicalities 4.5 SUMMARY OF KEY CONCEPTS Chapter 5: TOOLS OF THE TRADE IV. INTERFACES AND ION SOURCES FOR CHROMATOGRAPHY-MASS SPECTROMETRY 5.1 Introduction 5.2 ION SOURCES THAT CAN REQUIRE A Discrete interface between chromatograph and source 5.3. ION SOURCES NOT REQUIRING A DISCRETE INTERFACE 5.4SOURCE-ANALYZER INTERFACES BASED ON ION MOBILITY 5.5 SUMMARY OF KEY CONCEPTS APPENDIX 5.1 MALDI SPOT PREPARATION TECHNIQUES Chapter 6: TOOLS OF THE TRADE V. MASS ANALYZERS FOR QUANTITATION: SEPARATION OF IONS BY m/z VALUES 6.1 INTRODUCTION 6.2 Mass Analyzer Operation Modes and Tandem Mass Spectrometry 6.3 MOTION OF IONS IN ELECTRIC AND MAGNETIC FIELDS 6.4 MASS ANALYZERS 6.5 AcTivation and Dissociation of Ions 6.6 Vacuum systems 6.7 SUMMARY OF KEY CONCEPTS Chapter 7:TOOLS OF THE TRADE VI: ION DETECTION 7.1. INTRODUCTION 7.2 Faraday Cup detectors 7.3 Electron multipliers 7.4 Post-detectoR electronics Chapter 8: TOOLS OFTHE TRADE VII: STATISTICS OF SAMPLING, CALIBRATION AND MEASUREMENT INTRODUCTION 8.1 Systematic and random errors accuracy and precision 8.2 Univariate DATA: TOOLS AND TESTS FOR 8.3 DETERMINING ACCURACY AND PRECISION 8.4 Bivariate DATA: TOOLS AND TESTS FOR REGRESSION 8.5 AND CORRELATION 8.6 LIMITS OF DETECTION AND QUANTITATION 8.7 calibration and measurement: SYSTEMATIC AND RANDOM ERRORS8.8 Statistics of sampling of heterogeneous matrices 8.9 SUMMARY OF KEY CONCEPTS Appendix 8.1 A Brief Statistics Glossary Appendix 8.2 Symbols used in discussion of calibration methods Chapter 9. METHOD DEVELOPMENT AND FITNESS FOR PURPOSE 9.1 INTRODUCTION 9.2 FITNESS FOR PURPOSE AND MANAGING UNCERTAINTY 9.3 ISSUES BETWEEN ANALYST AND CLIENT: EXAMINING WHAT AT STAKE 9.4 FORMULATING A STRATEGY 9.5 METHOD DEVELOPMENT 9.6 MATRIX EFFECTS 9.7 CONTAMINATION AND CARRYOVER 9.8 ESTABLISHING THE FINAL METHOD Chapter 10: METHOD VALIDATION AND SAMPLE ANALYSIS IN A CONTROLLED LABORATORY ENVIRONMENT 10.1 INTRODUCTION 10.2 METHOD VALIDATION 10.3 CONDUCT OF THE VALIDATON 10.4 EXAMPLES OF METHODS AND VALIDATIONS FIT FOR PURPOSE 10.5 VALIDATED SAMPLE ANALYIS 10.6 DOCUMENTATION 10.7 TRACEABILITY Chapter 11: EXAMPLES FROM THE LITERATURE INTRODUCTION 11.2 FOOD CONTAMINANTS 11.3 ANTHROPOGENIC POLLUTANTS IN WATER 11.4 GC-MS ANALYSES OF PERSISTENT ENVIRONMENTAL POLLUTANTS 11.5 BIOANALYTICAL APPLICATIONS 11.6 QUANTITATIVE PROTEOMICS 11.7 ANALYSIS OF ENDOGENOUS ANALYTES

• ISBN: 978-0-470-05771-1
• Editorial: John Wiley & Sons
• Encuadernacion: Cartoné
• Páginas: 792
• Fecha Publicación: 11/04/2008
• Nº Volúmenes: 1
• Idioma: Inglés