Ureases: Functions, Classes, and Applications

Ureases: Foundations, Classes, and Applications provides a through, practical analysis of ureases-enzymes of growing relevance across a range of biotechnological applications and drug discovery. Unique in many aspects, ureases are one of the few enzymes to have nickel in their active sites. Ureases covers all aspects of this enzymatic class. Starting with foundational overview, the book discusses historical urease research and the current state, from basic biochemistry to the use of ureases as hallmarks in enzymology, crystallography and bioinorganic chemistry. The different classes of ureases, structurally diverse but chemically equivalent, are individually discussed. In addition, the multi-protein, multi-step activation of ureases (with chemical modification of residues, transport, and transfer of nickel ions) are examined in-depth, along with the catalytic mechanisms of ureolysis and its inhibitors. The final two sections of the book address multiple applications of ureases in health and biotechnology, respectively, going from gastric ulcer treatment to architectural uses in buildings and engineering. Future applications and next steps in research are also considered. Considers fundamental aspects of urease biochemistry, ureolysis and urease inhibitors Discusses urease research across a range of applications, from drug discovery to biosensors, water purification, architecture and the food industry Features chapter contributions from international leaders in the field INDICE: Part I. Introduction1. Ureases: an overview Part II. Historical aspects 2. Historical hallmarks in urease study 3. Plant urease genetics: A personal recollection Part III: Classes and special cases 4. Microbial tri-chain ureases 5. Microbial di-chain ureases 6. Plant ureases 7. Jack bean urease 8. Fungi ureases 9. Structural biology of ureases Part IV. Activation, catalysis, inhibition 10. Urease accessory proteins and enzyme activation 11. Catalysis mechanisms in ureases 12. Inhibition of ureases: studies and applications 13. Non-catalytic activities in ureases Part V. Health applications 14. Ureases as drug targets in stomach ulcers and cancer 15. Ureases as drug targets in urinary tract infections Chapter 16. Ureases as drug targets in fungal infections Part V. Biotechnological applications 17. Ureases and crop yield enhancement 18. Ureases as pesticides 19. Ureases and water purification 20. Ureases for structural and architectural applications21. Ureases in the beverage industry22. Ureases as biosensors 23. Immobilized ureases and their applications

• ISBN: 9780323918008
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 472
• Fecha Publicación: 17/02/2024
• Nº Volúmenes: 1
• Idioma: Inglés