Cancer genetics is a field of daunting breadth and depth. The literature describes hundreds of genes and genetic alterations that are variably associated with again as many disease states and risk factors. Integrating these disparatepieces of highly specialized information is challenging for the professional scientist and student alike. Prinicples of Cancer Genetics consolidates the main concepts of the cancer gene theory, and provides a framework for understanding the genetic basis of cancer. Focused on the most highly representative genes that underlie the most common cancers, Principles of Cancer Genetics is aimed at advanced undergraduates who have completed introductory courses in genetics, biology and biochemistry, medical students, and house medical house staffpreparing for board examinations. Primary attention is devoted to the originsof cancer genes and the application of evolutionary theory to explain why thecell clones that harbor cancer genes tend to expand. A concise guide to understanding the genes that cause cancer. Illuminates the integrated contributionsof heredity, the environment, and acquired genetic instability. Relates cancer genes to the hallmark characteristics of the cancer cell. Provides an overview of the genetic etiology of common cancers. Highlights new frontiers in gene-based diagnosis and therapy INDICE: From the contents Preface. 1: The Genetic Basis of Cancer. 2: Oncogenes. 3: Tumor Suppressor Genes. 4: Genetic Instability and Cancer. 5: CancerGene Pathways. 6: Genetic Alternations in Common Cancers. 7: Cancer Genetics in the Clinic. Appendix.
- ISBN: 978-1-4020-6783-9
- Editorial: Springer
- Encuadernacion: Cartoné
- Páginas: 340
- Fecha Publicación: 01/01/2008
- Nº Volúmenes: 1
- Idioma: Inglés