Catalytic Arylation Methods: From the Academic Labto Industrial Processes

A current view of the challenging field of catalytic arylation reactions. Clearly structured, the chapters in this one–stop resource are arranged according to the reaction type, and focus on novel, efficient and sustainable processes, rather than the well–known and established cross–coupling methods. The entire contents are written by two authors with academic and industrial expertise to ensure consistent coverage of the latest developments in the field, as well as industrial applications, such as C–H activation, iron and gold–catalyzed coupling reactions, cycloadditions or novel methodologies using arylboron reagents. A cross–section of relevant tried–and–tested experimental protocols is included at the end of each chapter for putting into immediate practice, along with patent literature. Due to its emphasis on efficient, green methods and industrial applications of the products concerned, this interdisciplinary text will be essential reading for synthetic chemists in both academia and industry, especially in medicinal and process chemistry. INDICE: 1 PRECEDENTS AND RAPID HISTORICAL REVIEW OF THE FIELD Metal–catalyzed Cross–Couplings: Origins to Nobel Prize Recent New Developments Conclusions Selected Experiments 2 CONJUGATE ADDITIONS Introduction Application of Rhodium Catalysts Application of Paladium Catalysts Application of Ruthenium and other Catalysts Conclusions Selected Experiments 3 IMINE ARYLATIONS – SYNTHESIS OF ARYLAMINES Introduction Application of Rhodium Catalysts Application of Palladium Catalysts Application of Ruthenium and other Catalysts The Petasis Reaction Conclusions Selected Experiments 4 CARBONYL GROUP ARYLATION Introduction Application of Rhodium Catalysts Application of Palladium Catalysts Application of Ruthenium and other Catalysts Conclusions Selected Experiments 5 C–H ACTIVATIONS Introduction C(sp2)–H Activations C(sp3)–H Activations Using Metal Catalysts Oxidative C–C Bond Formation Conclusions Selected Experiments 6 ALPHA–ARYLATION PROCESSES Arylation of Enolates and Equivalents Cross–Coupling Processes Conclusions Selected Experiments 7 IRON, COPPER AND GOLD CATALYZED CROSS–COUPLINGS Iron–catalyzed Processes – A more Ecological Approach with a Common Metal Copper–catalyzed Processes Gold–catalyzed Processes Conclusions Selected Experiments 8 DECARBOXYLATIVE COUPLING TECHNIQUES Palladium–catalyzed Versions Other Metal–catalyzed Versions Conclusions Selected Experiments 9 AMINE, PHENOL, ALCOHOL AND THIOL ARYLATION Introduction Palladium Catalysis (Buchwald–Hartwig Arylations) Copper Catalysis (Lam–Chan Coupling) Conclusions Selected Experiments 10 CATALYTIC CYCLOADDITIONS Cyclotrimerization of Alkynes ([2+2+2] Cycloadditions) Cocyclization Processes Conclusions Selected Experiments

• ISBN: 978-3-527-33518-3
• Editorial: Wiley VCH
• Encuadernacion: Cartoné
• Páginas: 400
• Fecha Publicación: 19/11/2014
• Nº Volúmenes: 1
• Idioma: Inglés