Senescence and Mitochondria Targeted Senotherapeutics

Developing senotherapeutic strategies is promising effective solutions for the sufferers of variety group of diseases including cancer. As known, senescent cells are closely associated with defective mitochondria, therefore, it is obvious that mitochondria have a great potential to be a target for developing a new senolytic agent. Considering this close relationship, all the therapeutic approaches can be basically classified as mitochondrial targets and extramitochondrial targets. Extramitochondrial targets of gerostatics, senostatics and senolytics having been considered extensively in various reviews and textbooks including those by the wide community of investigators, we have chosen not to deal with the same treatment in this book and focused on the senotherapeutic roles of various mitochondria-targeted pharmacoactive agents via basic and clinical perspectives. However, it still remains unclear why dysfunctional mitochondria occupy a central position in the development senescence-associated secretory phenotype (SASP) which may why draw the attention of the wide group of researchers. Mitochondrial dysfunction and SASP-related disease prognosis are closely interlinked to weaken immunity which is a common phenomenon in the etiologies of the diseases. Mitochondria are closely related to the survival of senescent cells, using either mitochondria-targeted senolytic or redox modulator senomorphic strategies may help us to solve the complex problems with the detrimental consequences of senescence. Killing of senescent cells and/or ameliorate their SASP-related negative effects are currently considered to be effective mitochondria-directed senotherapeutic approaches for fighting against senescence's outcomes This book would be the first of its kind. It differentiates from others with its multidisciplinary perspectives and multidimensional clinical approaches. Almost half of all sources about these books' content have been published during the last five years when PubMed database was searched with the keywords of senescence, mitochondria, and therapeutics. Which is evident that these issues are in increasing trend and our book must be published. Moreover, our authors are prominent in this area, which is a major benefit for the book, and all the authors have high scored H factors Offers a novel perspective on both basic and clinical sciences for wide group of the well-established academicians and students and researchers in medicinal chemistry, gerontology, geriatrics, oncology, pharmacology, pathology, bioinformatics, sports science, and nutritional sciences INDICE: 1. Cellular Senescence in Aging: Molecular Basis, Implications and Therapeutic InterventionsMadhu Dyavaiah2. Mitochondria-associated Cellular Senescence Mechanisms: Biochemical and Pharmacological PerspectivesUfuk Çakatay and Mehmet Can Atayik3. Mitochondria in cell senescence: Friend or Foe?Qian Chen4. The role of mitochondria and mitophagy in cell senescenceFatma Hussain5. Small molecules targeting mitochondrial dysfunction for potential senotheraputicsVishal Birar6. Senolytic and senomorphic interventions to defy senescence-associated mitochondrial dysfunctionJan O. Nehlin7. Mitochondrial targeting peptides and probes.Carmine Pasquale Cerrato8. Mitochondria-derived peptides in healthy ageing and therapy of age-related diseasesSiarhei Alexander Dabravolski9. Targeting of mitostasis-proteostasis axis by antioxidant polysaccharides in neurodegenerationZebo Huang10. Phytotherapeutic targeting of the mitochondria in neurodegenerative disordersKavitha Thirumurugan11. Melatonin as mitochondria-targeted drugsLuciano Saso and Sibel Suzen12. Coenzyme Q-related compounds to maintain healthy mitochondria during agingGuillermo López-Lluch Sr.13. Changing ROS, NAD and AMP: a path to longevity via mitochondrial therapeuticsOleh Lushchak14. Targeting mitochondrial dysfunction to salvage cellular senescence for managing neurodegenerationAbhishek Kumar Singh15. Targeting the microbiota-mitochondria crosstalk in neurodegeneration with senotherapeuticsJan Homolak16. Targeting senescent hematopoietic stem cell and regenerationLijian Shao17. Mighty mitochondria: The good and the bad side in senescence of Podospora anserinaVerena Warnsman

• ISBN: 978-0-443-18886-2
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 264
• Fecha Publicación: 01/07/2023
• Nº Volúmenes: 1
• Idioma: Inglés