Viruses are responsible for a variety of human, animal, and plant diseases and now represent potential agents of terror. Academic, government, and corporate laboratories have devoted years of effort to the development of strategies to prevent or treat viral infections. Central to the multiplication strategy ofall viruses is the process of genome replication. Enzymes critical to this step of the lifecycle have proven to be tractable targets for the development ofantiviral agents. Furthermore, genome replication is essential for virus spread and is the main target for the development of antiviral agents. By combining studies of both RNA and DNA viruses - and more - into a single volume, the editors have created a mechanism for cross-talk between the fields that will produce synergy and could lead to more rapid discovery of approaches to treat viral infections. INDICE: Genome replication strategies.- plus-strand RNA viruses.- Model ofPicornavirus RNA Replication.- Coronavirus Genome Replication.- Flaviviruses.- Hepatitis C virus genome replication.- Brome mosaic virus RNA replication and transcription.- Retroviruses.- Hepadnaviral genomic replication.- minus-strand RNA viruses.- Orthomyxoviruses genome transcription and replication.- ambisense RNA viruses.- Arenaviruses: Genome replication strategies.- dsRNA viruses.- Core-associated genome replication mechanisms of dsRNA viruses.- DNA viruses.- Poxviruses.- Herpesevirus genome replication.- Host factors.- Host factorspromoting replication.- Host factors that restrict retrovirus replication.- Elements, factors and enzymes: Structure-function and mechanism.- T4 Phage Replisome.- Atomic structure of the Herpes Simplex Virus 1 DNA polymerase.- RNA virus polymerases.- Human immunodeficiency virus reverse transcriptase.- Viral helicases.- Integrase: structure, function and mechanism.- Antivirals: Targets,mechanisms and resistance.- Viral DNA polymerase inhibitors.- RNA polymerase inhibitors.- HIV reverse transcriptase inhibitors and mechanisms of resistance.- Lethal mutagenesis.- Clinical implications of reverse transcriptase inhibitor resistance
- ISBN: 978-0-387-89425-6
- Editorial: Springer
- Encuadernacion: Cartoné
- Páginas: 622
- Fecha Publicación: 01/07/2009
- Nº Volúmenes: 1
- Idioma: Inglés