A variety of human and biological processes such as development, metabolism, aging, and disease are substantially affected by histone modifications and their control of gene expression regulation. In recent years, increasing evidence supports the potential of histone modifications to prevent and treat a wide range of disease types. Histone Modifications in Therapy provides researchers, clinicians, and students with in-depth analysis of the role of histone mechanisms in major diseases, and the promise of targeting histone modifications for disease prevention and treatment. Here, researchers, clinicians, and students will discover a thorough, evidence-based discussion of the biology of histones, the diseases engaged by aberrant histone modifications, and pathways with therapeutic potential. Expert chapter authors address the role of histone modifications across a variety of disorders, including cancer, neuropsychiatric, neurodegenerative, cardiac, metabolic, infectious, bacterial, autoimmune, and inflammatory disorders, among others. In relation to these disease types, histone modifications are discussed both as mechanisms of prevention and possible treatment. A concluding chapter brings together future perspectives for targeting histone modifications in therapy and next steps in research. Examines use of histone modifications in disease prevention and therapy Explores role of histone modifications in cancer, neuropsychiatric, neurodegenerative, cardiac, metabolic, infectious, bacterial, and inflammatory disease among other diseasesFeatures chapters from a broad range of international chapter authors and disease specialists INDICE: 1. Therapeutic perspectives for targeting histone modifications in mental retardation Anne Schaefer 2. Role of histone acetylation and methylation in depression 3. Epigenetic treatment of neurodegenerative diseases 4. Epigenetics: A novel therapeutic approach for the treatment of Alzheimer's disease 5. A prospective view of targeting histone modifications for Autism Spectrum Disorder Section II. Targeting histone modifications for cancer treatment 6. HDAC inhibitors in cancer therapy 7. Lysine methyltransferase drug targets in cancer 8. Targeting EZH2 in cancer 9. Targeting DOT1L for mixed lineage rearranged leukemia 10. Targeting bromodomains in cancer treatment and other diseases 11. Histone demethylase inhibitors and their potential in cancer treatment 12. IDH mutations in cancer and progress toward development of targeted therapeutics Section III. Targeting histone modifications for cardiovascular diseases and diabetes 13. Histone modification for cardiovascular prevention and therapeutics 14. Modulation of histone modification as a potential preventive and therapeutic approach for cardiovascular diseases 15. Epigenetics as an emerging approach to treat atherosclerosis 16. The potentiality of epigenetic drugs for diabetes and obesity 17. Epigenetic modifications for diabetic retinopathy 18. Targeting histone modifications in cancer immunotherapy 19. Epigenetic drug development for autoimmune and inflammatory diseases 20. Perspectives on epigenetic-based immune intervention for rheumatic diseases 21. The potential for targeted rewriting of epigenetic marks in Chronic obstructive pulmonary disease as a new therapeutic approach Section V. Targeting histone modifications for infectious disease 22. The therapeutic potential of epigenetic manipulation during infectious diseases 23. Targeting histone deacetylases for bacterial infections 24. Targeting histone methyltransferases EZH2/1 to suppress infection by diverse viral pathogens
- ISBN: 978-0-12-816422-8
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 424
- Fecha Publicación: 01/08/2020
- Nº Volúmenes: 1
- Idioma: Inglés