Endothelial Signalling in Vascular Dysfunction and Disease: From Bench to Bedside

Endothelial Signalling in Vascular Dysfunction and Disease: From Bench to Bedside provides a detailed understanding of the endothelium, its activation and how these are linked to some common clinical disorders. Additionally, history of earlier discoveries including those from the last century as well as from the 19th century reinforce the fact that research on basic biology is necessary to understand the development of diseases. The book is split into five sections: the vascular tree as an integrative structure; the endothelium in inflammation: signaling for vascular disease; endothelial signaling, activation and toxicity with chemotherapy; radiation induced endothelial dysfunction and vascular disease; and therapies in combating vascular diseases. Each section is discussed with a translational approach in order to make the content really applicable from bench to bedside. This book is a valuable source for basic researchers, clinicians in the fields of Oncology, Cardiovascular Medicine and Radiology, and several members of biomedical field conducting studies related with the endothelium and vascular disease. Discusses the most relevant discoveries in endothelial biology and their link to manifestation of clinical diseasePresents history and diagrams in each section to highlight the original biological discovery and its link of clinical manifestations of vascular diseaseIncludes recent findings on the relation between endothelial signaling and chemotherapy, and radiation induced endothelial dysfunction INDICE: Part I. The Vascular Tree as an Integrative Structure 1. The Vascular System: Components, Signaling and Regulation 2. ROS-induced ROS release in Vascular Signaling and Diseas 3. Nitric oxide as a vascular modulator to resistance training 4. Reactive Oxygen Species (ROS), Redox signaling and Regulation of Vascular Endothelial Signaling Part II: The Endothelium in Inflammation: Signaling for Vascular Disease 5. Inflammation and Coronary Artery Disease 6. An activated endothelium post Organ Transplantation: The Pathogenesis of Rejection 7. Neurovascular Unit: Intercellular Signaling and Translational Significance Part III. Endothelial Signaling, Activation and Toxicity with Chemotherapy 8. Signaling in the Tumor Vasculature 9. Chemotherapy induced Vascular Changes: Onset of Various Pathologies 10. Role of Angiogenesis in Wound Healing : Their impact in in Acute and Chronic Wound Healing 11. Normalization of the Tumor Vasculature 12. VEGF/VEGFR signaling in regulation of innate and adaptive immunity in solid tumors Part IV: Radiation Induced Endothelial Dysfunction and Vascular Disease 13. Human Radiation Exposures (Occupational, Medical, Environmental and Radiation Incidents) and Vascular Dysfunction 14. Flow adapted vascular systems: Mimicking the vascular network to predict clinical response to radiation 15. Radiotherapy and its effects on the tumor and normal vasculature 16. Effects of space radiation on the pulmonary endovasculature: implications for future human deep space exploration 17. Role of endothelial cells in normal tissue radiation injury Part V: Therapies in Combating Vascular Diseases 18. Experimental Models for Identifying Target Events in Vascular Injury 19. Hemeoxygenase and its Metabolites in Regulation of Vascular Endothelial Health 20. The endothelium as a target for bacterial infection RBC Conjugated agents in Prophylaxis: Challenges at the Bedside 21. Stents versus Scaffolds: Various Tools in Percutaneous Coronary Interventions 22. Statins in Deep Vein Thrombosis: Biochemical Approaches to limiting vascular Disease 23. Mathematical modeling approaches in understanding endothelial function 24. Endothelial dysfunction and vascular diseases. Uric acid and Oxidative stress 25. Comparative Assessment of Electrocardiographic Parameters of Some Bird -An Essential Diagnostic Tool in Veterinary practice 26. Conclusions, Future perspectives and Shifting paradigms in Endovascular Biology : From The Editor's Desk

• ISBN: 978-0-12-816196-8
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 300
• Fecha Publicación: 01/08/2020
• Nº Volúmenes: 1
• Idioma: Inglés