Modeling biomolecular networks in cells: structures and dynamics

Modeling Biomolecular Networks in Cells shows how the interaction between themolecular components of basic living organisms can be modelled mathematicallyand the models used to create artificial biological entities within cells. Such forward engineering is a difficult task but the nonlinear dynamical methodsespoused in this book simplify the biology so that it can be successfully understood and the synthesis of simple biological oscillators and rhythm-generators made feasible. Such simple units can then be co-ordinated using intercellular signal biomolecules. The formation of such man-made multicellular networks with a view to the production of biosensors, logic gates, new forms of integrated circuitry based on 'gene-chips' and even biological computers is an important step in the design of faster and more flexible 'electronics'. The book also provides theoretical frameworks and tools with which to analyze the nonlinear dynamical phenomena which arise from the connection of building units in a biomolecular network. Shows the reader how nature has often evolved different more efficient solutions from those produced by traditional human approaches tocircuits and systems Gives the reader mathematical tools to produce simplified models of molecular networks and interactions Demonstrates how simple biological systems can be synthesised with controllable properties facilitating their use in novel forms of electronics INDICE: Introduction.- Molecular Network in a Single Cell.- Switching Dynamics in a Single Cell.- Oscillating Dynamics in a Single Cell.- Introduction of Molecular Network in a Multi-cell System: A General Model.- Synchronization of Bio-oscillators without Noise.- Dynamical Control for Molecular Networks.- Network Motifs and Modules with Biological Functions in Molecular Networks.- Conclusion.

• ISBN: 978-1-84996-213-1
• Editorial: Springer
• Encuadernacion: Cartoné
• Páginas: 330
• Fecha Publicación: 29/09/2010
• Nº Volúmenes: 1
• Idioma: Inglés