Metal ions in metalloproteins are critical to the protein¿s function, structure, and stability. Because numerous essential biological functions require metal ions and most of these functions involve metalloproteins, understanding metalloproteins and how to manipulate them is of great importance in the biological and medical fields. This book examines current research on metalloproteins and the interplay between theory and experiment, detailing the role of theoretical modeling in the field and explaining how it aids experiments. The text also presents the current state of computational protein modeling, enabling researchers to adopt computation as an integral component of their studies. INDICE: Introduction. History of metalloprotein science. Recent surge in theoretical methods for study of metalloproteins. Roles, importance of metalloproteins in biology. Structures. X-ray structures of various metalloproteins including heme binding proteins. Ferritin structures. Quantum chemical calculations for study of metalloprotein structures. Functions. Functions of various metalloproteins including cytochrome. Quantum mechanics based simulation techniques that are applied to study functions of metalloproteins. Interactions. Interactions of metalloproteins with ligands. Interactions of metalloproteins withother proteins. Interactions of metalloproteins with DNA/RNA. QM/MM (quantum mechanical/molecular mechanical) based docking methods to study metalloproteininteractions.
- ISBN: 978-1-4398-1318-8
- Editorial: CRC Press
- Encuadernacion: Cartoné
- Páginas: 240
- Fecha Publicación: 01/07/2013
- Nº Volúmenes: 1
- Idioma: Inglés