Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies

Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies

Cho, Chi-Hin
Hu, Xuetao

161,20 €(IVA inc.)

Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies summarizes the molecular mechanisms of drug resistance in colorectal cancer and the up-to-date therapeutic strategies from leading scientists in the field in the world. It discusses reasons why colorectal tumors become refractory during the progression of the disease, but also explain how drug resistance occurred during chemotherapy. It also provides the current therapeutic strategies used by clinicians in their practice in treating colorectal cancer in humans. The combination of conventional anticancer drugs with chemotherapy-sensitizing agents plays a pivotal role in improving the therapeutic outcome of colorectal cancer patients, in particular those with drug-resistant cancer cells. From a clinical point of view, the content of this book provides clinicians with updated therapeutic strategies for a better choice of drugs for drug-resistant colorectal cancer patients. This book is a valuable source for cancer researchers, oncologists and several members of biomedical field who are dedicated to better treat patients with colorectal cancer and have the best outcome from chemotherapy. Presents a systemic summary of molecular mechanisms for a quick and in-depth understandingUpdates the current trends in the field with pioneer information in drug resistanceEncompasses both basic and clinical approaches for a better understanding of unsolved problems in a holistic way INDICE: 1. General introduction of drug resistance in colorectal cancer2. Drug transporters in the development of drug resistance in colorectal cancer3. Regulation of programmed cell death in drug-resistant colorectal cancer4. MicroRNAs and their relationship in drug resistance of colorectal cancer5. Cancer stem cells and drug resistance of colorectal cancer6. The role of tumour microenvironment in drug resistance of colorectal cancer7.  Development of chemosensitizing agents for colorectal cancer: in vitro and in animal models8. Clinical applications of combination treatments in colorectal cancer patients: current and clinical trials9.  Phytochemicals targeting drug resistance in colorectal cancer10.  Targeting drug resistance in colorectal cancer via novel delivery approaches

  • ISBN: 978-0-12-819937-4
  • Editorial: Academic Press
  • Encuadernacion: Cartoné
  • Páginas: 300
  • Fecha Publicación: 01/08/2020
  • Nº Volúmenes: 1
  • Idioma: Inglés