Statistics applied to clinical trials

The previous three editions of this book, rather than having been comprehensive, concentrated on the most relevant aspects of statistical analysis. Although well-received by students, clinicians, and researchers, these editions did not answer all of their questions. This updated and extended edition has been written to serve as a more complete guide and reference-text to students, physicians, and investigators, and, at the same time, preserves the common sense approach to statistical problem-solving of the previous editions. In 1948 the first randomized controlled trial was published by the English Medical Research Council in the British Medical Journal. Until then, observations had been uncontrolled. Initially, trials frequently did not confirm hypotheses to be tested. This phenomenon was attributed to little sensitivity due to small samples, as well as inappropriate hypotheses based on biased prior trials. The authors have both medical and mathematical backgrounds Based on famous modules from theSocrates educational project Eudipharm of the EC Innovative because of the explanatory rather than mathematical approach Emphasizes non-classical but increasingly frequently used methods such as equivalence testing, interaction assessment and analysis of genetic data Not equivalent to any current textbook on statistics

• ISBN: 978-1-4020-9522-1
• Editorial: Springer
• Encuadernacion: Cartoné
• Páginas: 562
• Fecha Publicación: 01/02/2009
• Nº Volúmenes: 1
• Idioma: Inglés