The collection of systems represented in this volume is an effort to reflect the diversity and utility of models that are used in biomedicine. That utilityis based on the consideration that observations made in particular organisms will provide insight into the workings of other, more complex systems. Some models have the advantage that the reproductive, mitotic, development or aging cycles are rapid compared with those in humans; others are utilized because individual proteins may be studied in an advantageous way and have human homologs. Other organisms are facile to grow in laboratory settings, lend themselves to convenient analyses, have defined genomes or present especially good human models of human or animal disease. Sourcebook of Models for Biomedical Researchis a comprehensive and extensive collection of these important medical parallels. Unique reflection of the diversity and utility of models used in biomedicine INDICE: From the contents Animal models for human diseases: an overview.- Selection of biomedical animal models.- Improved models for animal research.- The ethical basis for animal use in research.- Bibliographic searching tools on disease models to locate alternatives for animals in research: A website companion.- NIH policies on sharing of model organisms and related research resources.- Databases for biomedical animal resources.- Psychological enrichment for animals in captivity.- Integrated network modeling of molecular and genetic interactions.- The sponge as a model of cellular recognition.- Sea urchin embryo - a model system for analyzing a variety of cellular activities during early development.- C. elegans models of human neurodegenerative deseases: a powerful tool to identify molecular mechanisms and novel therapeutic targets.- Zebrafish as a model for development.- Zebrafish as a model for studying adult effects of challenges to the embryonic nervous system.
- ISBN: 978-1-58829-933-8
- Editorial: Humana
- Encuadernacion: Cartoné
- Páginas: 920
- Fecha Publicación: 01/02/2008
- Nº Volúmenes: 1
- Idioma: Inglés