The importance of metals in biology, the environment and medicine has become increasingly evident over the last twenty five years. The study of the multiple roles of metal ions in biological systems, the rapidly expanding interface between inorganic chemistry and biology constitutes the subject called Biological Inorganic Chemistry. The present text, written by a biochemist, with a longcareer experience in the field (particularly iron and copper) presents an introduction to this exciting and dynamic field. The book begins with introductory chapters, which together constitute an overview of the concepts, both chemical and biological, which are required to equip the reader for the detailed analysis which follows. Pathways of metal assimilation, storage and transport, aswell as metal homeostasis are dealt with next. Thereafter, indivbidual chapters discuss the roles of sodium and potassium, magnesium, calcium, zinc, iron, copper, nickel and cobalt, manganese, and finlly molybdenum, vanadium, tungsten and chromium. The final three chapers provide a tantalising view of the roles of metals in brain function, biomineralization and a brief illustration of their importance in both medicine and the environment. INDICE: The role of metals in biology – an overview Basic coordination chemistry for biologists Structural and molecular biology for chemists Biologicalligands for metal ions An overview of intermediary metabolism and bioenergetics Methods which can be used to study metals in biology Metal assimilation pathways Transport, storage and homeostasis of metal ions Sodium and potassium Calcium Magnesium Zinc Iron Copper Nickel and cobalt Manganese Molybdenum, vanadium, tungsten and chromium Metals in brain function Biomineralisation Metals in medicine and the environment Concluding remarks.
- ISBN: 978-0-444-52740-0
- Editorial: Elsevier Science
- Encuadernacion: Rústica
- Páginas: 369
- Fecha Publicación: 01/01/2008
- Nº Volúmenes: 1
- Idioma: Inglés