Adenoviral Vectors for Gene Therapy, Second Edition provides detailed, comprehensive coverage of the gene delivery vehicles that are based on the adenovirus that is emerging as an important tool in gene therapy. These exciting new therapeutic agents have great potential for the treatment of disease, making gene therapy a fast-growing field for research. This book presents topics ranging from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology, and the use of adenoviral vectors in preclinical animal models, with final consideration of the regulatory issues surrounding human clinical gene therapy trials. This broad scope of information provides a solid overview of the field, allowing the reader to gain a complete understanding of the development and use of adenoviral vectors. Provides complete coverage of the basic biology of adenoviruses, as well as their construction, propagation, and purification of adenoviral vectorsIntroduces common strategies for the development of adenoviral vectors, along with cutting-edge methods for their improvementDemonstrates noninvasive imaging of adenovirus-mediated gene transferDiscusses utility of adenoviral vectors in animal disease modelsConsiders Federal Drug Administration regulations for human clinical trials INDICE: Adenovirus Structure Biology of Adenovirus Cell Entry Adenovirus Replication Adenoviral Vector Construction I: Mammalian Systems, Adenoviral Vector Construction II: Bacterial Systems Propagation of Adenoviral Vectors: Use of PER.C6 Cells Purification of Adenovirus Targeted Adenoviral Vectors I: Transductional Targeting Targeted Adenoviral Vectors II: Transcriptional Targeting Development of Attenuated Replication Competent Adenoviruses (ARCAs) for the treatment of Prostate Cancer Replication-Selective Oncolytic Adenovirus EI-Region Mutants: Virotherapy for Cancer Innate Immune Responses to in Vivo Adenovirus Infection Humoral Immune Response Novel Methods to Eliminate the Immune Response to Adenovirus Gene Therapy High-Capacity Gutless Adenoviral Vectors: Technical Aspects and Applications Xenogenic Adenoviral Vectors Hybrid Adenoviral Vectors Utiliity of Adenoviral Vectors in Animal Models of Human Disease I: Cancer Utiltity of Adenoviral Vectors in Animal Models of Human Disease II: Genetic Disease Utility of Adenoviral Vectors in Animal Models of Human Disease III: Acquired Diseases Testing of Adenoviral Vector Gene Transfer Products: FDA Expectations Imaging Adenovirus-Medicated Gene Transfer
- ISBN: 978-0-12-800276-6
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 868
- Fecha Publicación: 20/03/2016
- Nº Volúmenes: 1
- Idioma: Inglés