Zika Virus and Diseases: From Molecular Biology to Epidemiology

Compiles the most current information on the Zika virus and its associated diseases  This comprehensive book provides the most up–to–date information for students, medical students, and scientists on Zika virus and its associated diseases. It includes all the information related to the Zika virus since its discovery in 1947; its epidemic outbreak in 2007–2014; how the epidemiology changed in America in 2015–2016; its mode of transmission; how to prevent and treat it; and associated diseases. Zika Virus and Diseases: From Molecular Biology to Epidemiology offers complete and up–to–date coverage in 10 chapters. It presents information from papers that attempted to associate the virus with diseases in Africa until the first animal experiment; discusses its association with Guillain–Barré syndrome and microcephaly; describes the basic mechanisms for Zika (ZIKV) replication, including important differences between Dengue (DENV), West–Nile virus (WNV), and ZIKV; explains the difference between the strains and discusses the pathogenesis of them; covers the papers that showed all the interferences that Zika can cause, and the pathways which can be modified; and more. The first book since 1947 to put together all the scientific information Compiles all the information received in the last year about Zika virus Clearly demonstrates the origin and discovery of the virus Zika Virus and Diseases: From Molecular Biology to Epidemiology will appeal to graduate students, medical students, basic researchers, clinicians in infectious disease, microbiology, and virology, as well as people in related disciplines interested in learning more about this topic. INDICE: PrefaceList of Abbreviations .Chapter 1: The history of ZIKV discovery1.1 ZIKV isolation from monkeys and mosquitos1.2 ZIKV infection in humans1.3 ZIKV infection spread to other hosts and regions1.4 Cross–paths between ZIKV and other flavivirusesReferences .Chapter 2: ZIKV: From silent to epidemic2.1 Outbreak in Yap Island (2007)2.2 Outbreak in French Polynesia (2013)2.3 How did ZIKV reach Brazil?2.4 Outbreak in Brazil (2015)2.5 ZIKV spread through South, Central and North AmericasReferences .Chapter 3: ZIKV Transmission and Prevention3.1 Modes of Transmission3.2 PreventionReferences .Chapter 4: Association with Guillain–Barré syndrome and microcephaly4.1 Association with neurological disordersReferences .Chapter 5: ZIKV animal models5.1 Animal models: Embryonated hen eggs5.2 Animal models: Landrace piglet5.3 Animal models: Mice5.4 Animal model non–human primateReferences .Chapter 6: Biology of ZIKV6.1 Structural and physical properties of ZIKV virion6.2 Binding and entry6.3 Genome structure6.4 Translation and proteolytic processing6.5 Features of the non–structural proteins6.6 RNA replication6.7 Features of the structural proteins6.8 Virus assembly and release from virus–infected cellsReferences .Chapter 7: Zika virus (ZIKV) strains and lineages7.1 East and West African lineage7.2 Africa vs. Asian/American lineageReferences .Chapter 8: ZIKV–host interactions8.1 Systematic studies to identify ZIKV affected functions and pathways8.2 Induction and dysregulation of innate immune responses during ZIKV infection8.3 Induction of cell death and apoptosis by ZIKV8.4 Induction of autophagy by ZIKV8.5 Dysregulation of cell cycle and induction of abnormal mitosis by ZIKVReferences .Chapter 9: Inhibitors of ZIKV replication and infection9.1 Drugs that lead to the destruction of ZIKV virions9.2 Drugs that inhibit ZIKV entry and endocytosis9.3 Drugs that target ZIKV NS2B–NS3 protease activity9.4 Drugs that target ZIKV NS5 RNA–dependent RNA polymerase activity9.5 Neutralizing antibodies that target ZIKV structural protein9.6 Drugs that inhibit ZIKV infection by targeting host machinery9.7 Drugs that show neuroprotective activity but do not suppress ZIKV replication9.8 Other drugs that inhibit ZIKV infection identified from a screening of FDA–approved drugsReferences .Chapter 10: Long–term care and Perspectives10.1 Prenatal care and diagnosis of abnormal fetus development10.2 Long–term care for patients affected by ZIKV10.3 Assistance to families with children affected by ZIKV10.4 PerspectivesReferences .Index

• ISBN: 978-1-119-40864-2
• Editorial: Wiley–Blackwell
• Encuadernacion: Cartoné
• Páginas: 264
• Fecha Publicación: 18/04/2018
• Nº Volúmenes: 1
• Idioma: Inglés