Organs and Organoids combines contributions from leading practitioners in the field, under the editorial control of one researcher who has been in the field for many years, and was for 8 years the Editor in Chief of the journal Organogenesis, the first journal in this area. The book begins with an introduction. Next, a set of chapters present advice on making organoids for many different systems. These are followed by case studies illustrating the uses to which organoids can be put. The book ends with an indication of likely future directions and the specific problems that need to be solved Collects the best protocols of organoid cultures from diverse tissuesCovers a wide range of organsIncludes troubleshooting cases for common but specific problems for each culture conditionsEntire unit on the application of organoids INDICE: Section 1: Introduction 1. overview of the technology and nomenclature (Jamie Davies) Section 2: Construction (each chapter reviews the technology and ends with a 'recipe') 2. Neurospheres (Michael Geusz - has the circadian rhythm story) 3. Cerebral cortex (Madeline Lancaster) 4. Midbrain (Karl-Heinz Krause) 5. Optic cup (Yoshiki Sasai) 6. Inner ear (Eri Hashino) 7. Gut (Owen Sansom, Glasgow) 8. Liver (Yo-ichi Tagawa) 9. Lung (Jason Spence) 10. Mammary gland (Charles Streuli or Andrew Ewald) 11. Prostate (Gail Prins or Michael Shen) 12. Immuno (Ankur Singh) 13. Thymus (Clare Blackburn) 14. Ovary (Norah Spears) 15. Kidney (Jamie Davies) Section 3: Application 16. Physiology/ Pharmacology 17. Use of multiple organoids to represent multi-organ systems (Uwe Marx? - the liver/ neuropshere story) 18. Infection 19. Stomach organoids to study Helicobacter (Richard M Peek) 20. Gut organoids to study Salmonella (Jun Sun) 21. Cancer 22. Recreating tumours by modifying genes in organoids (Toshiro Sato) 23. High-throughput techniques for drug screening. Section 4: conclusion 24. Opportunities and likely future developments (Jamie Davies)
- ISBN: 978-0-12-812636-3
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 525
- Fecha Publicación: 01/03/2018
- Nº Volúmenes: 1
- Idioma: Inglés