Introduction.-Probing Astrocyte Function in Fragile X Syndrome. Neural Stem Cells. Fragile X Mental Retardation Protein (FMRP) and the Spinal Sensory System.- The Role of the Postsynaptic Density in the Pathology of the Fragile X Syndrome. Behavior in a Drosophila model of Fragile X. Molecular and Genetic Analysis of the Drosophila Model of Fragile X Syndrome. Fragile X Mental Retardation Protein and Stem Cells. Manipulating the Fragile X Mental Retardation Proteins in the Frog. Exploring the Zebra finch Taeniopygia gutta as a Novel AnimalModel for the Speech-language Deficit of Fragile X Syndrome. Neuroendocrine Alterations in the Fragile X Mouse. Taking STEPs forward to understanding Fragile X Syndrome. Fmr-1 as an Offspring Genetic and a Maternal Environmental Factor in Neurodevelopmental Disease. Mouse Models of the Fragile X Premutation and the Fragile X Associated Tremor/Ataxia Syndrome. Clinical Aspects of the Fragile X Syndrome. Fragile X Syndrome: A Psychiatric Perspective. Fragile X Syndrome and Targeted Treatment Trials. The Fragile X-associate Tremor Ataxia Syndrome. Vignettes: Models in Absentia. Comprehensive overview on the molecular basis of fragile X syndrome. Firstbook to cover all models used to investigate fragile X syndrome. Includes state-of-of the art approaches like epigenetics. INDICE: Introduction: Reminiscing on Models and Modeling. Probing Astrocyte Function in Fragile X Syndrome. Neural Stem Cells. Fragile X Mental Retardation Protein (FMRP) and the Spinal Sensory System. The role of the postsynapticdensity in the pathology of the fragile X syndrome. Behavior in a Drosophila model of Fragile X. Molecular and Genetic Analysis of the Drosophila Model of Fragile X Syndrome. Fragile X Mental Retardation Protein and Stem Cells. Manipulating the Fragile Mental Retardation Proteins in the frog. Exploring the zebra finch Taeniopygia guttata as a novel animal model for the speech-language deficit of fragile X syndrome. Neuroendocrine alterations in the fragile X mouse. Taking STEPs forward to understanding Fragile X Syndrome. Fmr-1 as an offspring genetic and a maternal environmental factor in neurodevelopmental disease. Mouse Models of the Fragile X Premutation and the Fragile X Associated Tremor/Ataxia Syndrome. Clinical Aspects of the Fragile X Syndrome. Fragile X Syndrome: A Psychiatric Perspective. Fragile X Syndrome and Targeted Treatment Trials. The Fragile X-associated Tremor Ataxia Syndrome. Vignettes: Models in Absentia.
- ISBN: 978-3-642-21648-0
- Editorial: Springer Berlin Heidelberg
- Encuadernacion: Cartoné
- Páginas: 390
- Fecha Publicación: 30/11/2011
- Nº Volúmenes: 1
- Idioma: Inglés