Dynamic-clamp is a fascinating electrophysiology technique that consists of merging living neurons with computational models. The dynamic-clamp (also called “conductance injection”) allows experimentalists and theoreticians to challenge neurons (or any other type of cell) with complex conductance stimuli generated by a computer. The technique can be implemented from neural simulation environments and a variety of custom-made or commercial systems. The real-time interaction between the computer and cell also enables the design of recording paradigms with unprecedented accuracy via a computational model of the electrode. Dynamic-Clamp: From Principles to Applications contains contributions fromleading researchers in the field, who investigate these paradigms at the cellular or network level, in vivo and in vitro, and in different brain regions and cardiac cells. INDICE: From the contents 1: Associating living cells and computational models: from basics to present applications of the dynamic-clamp. 2: Dendritic dynamic clamp – a tool to study single neuron computation. 3: Synaptic conductances and spike generation in cortical cells. 4: Simulating In Vivo Background Activity in a Slice with the Dynamic Clamp. 5: Impact of background synaptic activity on neuronal response properties revealed by stepwise replication of invivo-like conditions in vitro. 6: Testing methods for synaptic conductance analysis using controlled conductance injection with dynamic clamp. 7: Functional roles of shunting inhibition and IBK in rat and cat cortex. 8: Functions of the persistent Na+ current in cortical neurons revealed by dynamic clamp. 9: Using "Hard" Real-Time Dynamic Clamp to Study Cellular and Network Mechanisms of Synchronization in the Hippocampal Formation. 10: Unraveling the dynamics ofdeep cerebellar nucleus neurons with the application of artificial conductances.
- ISBN: 978-0-387-89278-8
- Editorial: Springer
- Encuadernacion: Cartoné
- Páginas: 410
- Fecha Publicación: 01/04/2009
- Nº Volúmenes: 1
- Idioma: Inglés