Epigenetics in Cardiovascular Disease, a new volume in the Translational Epigenetics series, offers a comprehensive overview of the epigenetics mechanisms governing cardiovascular disease development, as well as instructions in research methods and guidance in pursing new studies. More than thirty international experts provide an (i) overview of the epigenetics mechanisms and their contribution to cardiovascular disease development, (i) high-throughput methods for RNA profiling including single-cell RNA-seq, (iii) the role of nucleic acid methylation in cardiovascular disease development, (iv) epigenetic actors as biomarkers and drug targets, (v) and the potential of epigenetics to advance personalized medicine. Here, readers will discover strategies to combat research challenges, improve quality of their epigenetic research and reproducibility of their findings. Additionally, discussion of assay and drug development for personalized healthcare pave the way for a new era of understanding in cardiovascular disease. Offers a thorough overview of role of epigenetics mechanisms in cardiovascular diseaseIncludes guidance to improve research plans, experimental protocols design, quality and reproducibility of results in new epigenetics researchExplores biomarkers and drug targets of therapeutic potential to advance personalized healthcareFeatures chapter contributions from a wide range of international researchers in the field INDICE: Section I: Introductory information 1. The ever-growing burden of cardiovascular disease 2. Epigenetics concepts - an overview 3. From classical signalling pathway to the nucleus Section II: Epigenetics mechanisms in cardiovascular disease 4. DNA methylation in cardiovascular disease development 5. Histone modifications in cardiovascular disease initiation and progression 6. Post transcriptional RNA modifications in cardiovascular disease 7. Regulatory RNAs in cardiovascular disease 8. Regulation of splicing in cardiovascular disease 9. Cardiac Transcriptomic Remodelling in Metabolic Syndrome 10. Sex differences in epigenetics mechanisms of cardiovascular disease 11. Epigenetics of cardiac development and iPS cells Section III: Biomarker value 12. Peripheral Blood DNA and RNA Biomarkers of Cardiovascular Disease in Clinical Practice 13. Epigenetics and physical exercise 14. Long non-coding RNAs and circular RNAs as heart failure biomarkers 15. Artificial intelligence in clinical decision-making for diagnosis of cardiovascular disease Section IV: Therapeutic potential 16. Therapeutic strategies for modulating epigenetic mechanisms in cardiovascular disease Section V: Methodological issues 17. RNA-sequencing and single cell RNA-seq in cardiovascular medicine 18. Good laboratory and experimental practices for microRNA analysis in cardiovascular research 19. Analytical challenges in microRNA biomarker development - Best practices for analyzing microRNAs in cell-free biofluids 20. Concept of biological reference materials for RNA analysis in cardiovascular disease 21. Unbiased bioinformatics analysis of microRNA transcriptomics datasets and network theoretic target prediction
- ISBN: 978-0-12-822258-4
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 416
- Fecha Publicación: 01/03/2021
- Nº Volúmenes: 1
- Idioma: Inglés