Water Extraction of Bioactive Compounds: From Plants to Drug Development

Water Extraction of Bioactive Compounds: From Plants to Drug Development draws together the expert knowledge of researchers from around the world to outline the essential knowledge and techniques required to successfully extract bioactive compounds for further study. The book is a practical tool for medicinal chemists, biochemists, pharmaceutical scientists and academics working in the discovery and development of drugs from natural sources. The discovery and extraction of bioactive plant compounds from natural sources is of growing interest to drug developers, adding greater fuel to a simultaneous search for efficient, green technologies to support this. Particularly promising are aqueous based methods, as water is a cheap, safe and abundant solvent. The book is a detailed guide to the fundamental concepts and necessary equipment needed to successfully undertake such processes, supported by application examples and highlighting the most influential variables. Part 1 begins with a thorough introduction to plants as sources of drugs, highlighting strategies for the discovery of novel bioactive constituents of botanicals, the need for standardization and a move toward more rational and greener techniques in the field, the development of plant-based extraction processes and pretreatments for the efficient extraction. Part 2 then reviews a broad range of available techniques, including sections on conventional hot water extraction and pressurized hot water extraction in a range of settings. Intensified processes are then discussed in detail, including sections on microwave-assisted processes, ultrasound-assisted processes and enzyme assisted extraction. Covers the theoretical background and range of techniques available to researchers, helping them to select the most appropriate extraction method for their needsPresents up-to-date and cutting edge applications by international expertsHighlights current use and future potential for industrial scale applicationsOffers a thorough introduction to plants as sources of drugs, highlighting strategies for the discovery of novel bioactive constituents of botanicals INDICE: PART I. 1. Plant as source of drugs. Constituents and biological actions 2. Strategies in drug discovery of novel bioactive constituents of botanicals 3. The need of standardization of botanicals and herbal preparations 4. Towards more rational techniques for the isolation of valuable compounds from plants 5. Searching for green solvents: water 6. Process Development of Plant-Based Extraction Processes 7. Pretreatments for the efficient extraction of bioactive compounds from plants PART II.  Conventional hot water extraction 8. Aqueous extracts with medicinal properties Pressurized hot water extraction 9. Solubility of plant active compounds in superheated water 10. Hydrolysis of biopolymers in near critical and subcritical water 11. Neoformation of antioxidants in glycation model systems treated under subcritical water extraction conditions 12. Reactor configurations for subcritical water extraction 13. Production of amino and organic acids from protein using sub-critical water technology 14. Extraction of functional substances from agricultural products or by products by subcritical water treatment 15. Pressurized hot water extraction of botanicals and medicinal plants 16. Conversion of alpha-zein to an angiotensin I-converting enzyme inhibitor under supercritical water conditions 17. Silymarin Extraction from Silybum marianum L. Gaertner Intensified processes Microwave-assisted processes 18. Fundamentals of microwave assisted extraction processes 19. Microwave-assisted extraction of medicinal plants 20. Influence of microwave heating on the stability of plant compounds 21. Effect of dielectric microwave heating on the color and antiradical capacity of betanin 22. Microwave-assisted extraction of flavonoids 23. Solvent free extraction processes using ultrasound and microwave techniques to obtain essential oil, polyphenols and pectin 24. Microwave superheated water of arabinoxylooligosaccharides 25. Microwave-assisted extraction of bioactive compounds from cabbage leaves US-Assisted Extraction 26. Fundamentals of Ultrasound assisted extraction. 27. Molecular properties and antioxidant activities of polysaccharide-protein complexes from selected mushrooms by ultrasound-assisted extraction 28. Degradation during application of ultrasound in food processing: A review 29. Modeling approaches to optimize the ultrasounds assisted extraction of antioxidant compounds from plants 30. Ultrasound-assisted extraction of amino acids from grapes 31. US assisted extraction of polysaccharides Enzyme assisted extraction 32. Enzyme hydrolytic activities for assisting in cell breakage 33. Commercial enzymes 34. Aqueous enzyme assisted oil extraction and emulsion de-emulsifying methods 35. Enzyme-Assisted Aqueous Extraction of Soybeans 36. Downstream processing of stevioside and its potential applications 37. Enzyme-assisted extraction of flavorings and colorants

• ISBN: 978-0-12-809380-1
• Editorial: Elsevier
• Encuadernacion: Rústica
• Páginas: 650
• Fecha Publicación: 01/09/2017
• Nº Volúmenes: 1
• Idioma: Inglés