Oral drug absorption: prediction and assessment

REVISION OF A BESTSELLER - Updated to include recent advances in pharmacokinetic modeling and profiling, keeping pharmaceutical scientists up-to-date INTERACTIVE CD-ROM - with an Excel program that allows readers to expertly model and analyze their own data EXPERIENCED PANEL OF CONTRIBUTORS - that includes lding FDA and USP scientists, providing the most current, accurate informationreaders want and can trust. THE FUNDAMENTALS - Discusses the qualification, calibration, and maintenance of dissolution testing equipment using high quality photographs and diagrams to illustrate key points BROAD, INTERNATIONAL COVERAGE - on the requirements of dissolution testing by comparing three of the most widely used pharmacopoeia, namely the US, European, and Japanese Pharmacopoeia, giving readers pertinent data from a global perspective INDICE: I: Physiology of Oral Drug Absorption. General Gastrointestinal Physiology relevant to drug absorption. Absorption mechanisms in the GI tract. Gastrointestinal Transit and Drug Absorption. Gut Wall Metabolism. Food effectson dosage form performance. Diseases affecting drug absorption. II: The Biopharmaceutics Classification System. The Biopharmaceutics Classification Scheme.Solubility in the GI tract. Permeability measurement. In vivo biopharmaceutics: Experience from intestinal perfusion in humans. Alternatives to BCS using First Pass metabolism in the gut and liver. III: I Non-clinical methods to evaluate oral formulations. Dissolution testing to forecast in vivo performance ofIR formulations. Dissolution testing to forecast in vivo performance of MR formulations. Analysis of Drug Dissolution Data. Formulation Screening in the Pharmaceutical Industry I. Formulation Screening in the Pharmaceutical Industry II. Animal models for screening oral formulations - an update. Computer modelsfor predicting drug absorption. IV: Bioequivalence studies. Bioavailability and Bioequivalence studies. Biowaiving based on the BCS - A Global Comparison. Biowaiving based on IVIVC. Appendix: Excel sheet programme (as CD).

• ISBN: 978-1-4200-7733-9
• Editorial: Informa Healthcare
• Encuadernacion: Cartoné
• Páginas: 425
• Fecha Publicación: 01/03/2010
• Nº Volúmenes: 1
• Idioma: Inglés