Insertional mutagenesis strategies in cancer genetics

The goal of this work is summarize the contribution that insertional mutagenesis has made to our understanding of cancer. A variety of insertional mutagensare presented that have been used to study a variety of tumor types in several model organisms. In addition, the impact of insertional mutagenesis in several gene therapy trials is discussed along with strategies to avoid such complications in future clinical trials. This work summarizes the contribution that insertional mutagenesis has made to our understanding of cancer A variety of insertional mutagens are presented that have been used to study a variety of tumor types in several model organisms The impact of insertional mutagenesis in several gene therapy trials is discussed along with strategies to avoid such complications in future clinical trials INDICE: Chapter 1: Introduction: Author: Anton Berns (Netherlands Cancer Institute).- Chapter 2: Retroviral mutagenesis in mouse leukemia/lymphoma: Author: David Largaespada, Ph.D. (University of Minnesota).- Chapter 3: MMTV models of breast cancer: Author: John Hilkens (NKI).- Chapter 4: Retroviral mutagenesis in other organisms: Author: Michael Dvorak (Inst. Of Molecular Genetics, Prague, Czech Rep.).- Chapter 5: Sleeping Beauty models of cancer: Author: Adam J. Dupuy, Ph.D. (University of Iowa).- Chapter 6: Insertional mutagenesis ingene therapy patients: Author: David Williams, M.D. (Cincinnati Children’s Hospital).- Chapter 7: Bioinformatics of high throughput insertional mutagenesis: Author: Keiko Akagi (NCI-Frederick).

• ISBN: 978-1-4419-7655-0
• Editorial: Springer
• Encuadernacion: Cartoné
• Páginas: 150
• Fecha Publicación: 04/01/2011
• Nº Volúmenes: 1
• Idioma: Inglés