For biomaterials, oxidative stress poses an especially troubling challenge to their biocompatibility. No material is in all biological settings and situations 100% non-inflammatory, non-toxic, non-teratogenic, non-carcinogenic, non-thrombogenic, and non-immunogenic. At the cellular level, the tissue environment is a harsh landscape of precipitating proteins, infiltrating leukocytes, released oxidants and fluctuations of pH, which even with the slightest shift in stasis can induce a perpetual state of chronic inflammation. While in this embattled terrain, the most we can hope for from the biomaterials we design is a type of meso-compatibility,? a material which can remain functional and benign for as long as required without succumbing to this cellular onslaught and inducing a local inflammatory reaction. Explores the challenges of designing and using biomaterials in order to minimize oxidative stress, reducing patterns of chronic inflammation and cell deathBrings together the two fields of biomaterials and the biology of oxidative stressProvides approaches for the design of biomaterials with improved biocompatibility INDICE: Section I. Basic Principles and Current Understanding Chapter 1. Free Radical Chemistry PrimerChapter 2. Oxidative stress, Inflammation and DiseaseChapter 3. Biomaterial Biocompatibility: Current Understanding and Basics Chapter 4. Oxidative Stress and Biomaterials: The Inflammatory LinkChapter 5. Nanoparticle Toxicity and Environmental ImpactSection II. Analytical Tools Chapter 6. In Vitro -Cell Free Systems for Oxidative stress analysisChapter 7. In Vitro- Cellular Assay for Oxidative stress and Biomaterial ResponseChapter 8. In Vivo Assays for Oxidative stress and Biomaterial BiocompatibilityChapter 9. Emerging Technologies and needs in Oxidative stress analysisSection III. Incorporating Oxidative Stress into Biomaterial Design Chapter 10. Oxidation State as a Bioresponsive TriggerChapter 11. Antioxidant Polymers as a Biomaterial or Therapeutic choiceChapter 12. Metal Nanoparticle AntioxidantsChapter 13. Oxidative Stress and Cancer TherapyChapter 14. Immunomodulatory Biomaterials
- ISBN: 978-0-12-803269-5
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 432
- Fecha Publicación: 01/06/2016
- Nº Volúmenes: 1
- Idioma: Inglés