Communication between different organs involves lipids and other small molecules and a host of proteins and peptides comprising the secretome of different organs (organokinome). More than 600 adipokines have been identified and an increasing number of hepatokines and myokines have recently been discovered with mostly unknown physiological impact. Importantly, an aberrant signature of the organokinome may be critically underlying a variety of metabolic diseases and may determine the individual susceptibility to disease development. There is a need for a book that comprehensively describes the current knowledge of secretome biology in health and disease. This book does that. The Cellular Secretome and Organ Crosstalk focuses on the release of peptides and proteins from different organs and their specific functions in metabolic regulation and cell- and organ crosstalk. The book is written for experts in the field. However, for each topic helpful references are included for the less experienced readers. A technical part summarizing the state-of-the-art of secretome and crosstalk analysis is included as a final chapter. Summarizes our current knowledge on the secretome of different cells and tissuesDissects auto-, para-, and endocrine functions of major secreted peptides and proteinsAnalyses secretory malfunction of different cells and its impact for disease developmentAuthored by a leader in the fieldA single authored book ensures a coherent view on this very complex topic INDICE: 1. General Introduction2. Adipose tissue - a major secretory organ3. Skeletal muscle - a novel secretory organ4. Adipomyokines - an integrated view on the fat/muscle axis5. Organokines - an extended view on the crosstalk scenario6. Secretory malfunction - a key step to metabolic diseases7. Conclusion and outlook8. Technical Annex: Secretome and crosstalk analysis
- ISBN: 978-0-12-809518-8
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 400
- Fecha Publicación: 01/03/2018
- Nº Volúmenes: 1
- Idioma: Inglés