Exosomes in Health and Disease: A Research and Clinical Compendium

Exosomes in Health and Disease serves as the first comprehensive overview of the physiologic and clinical importance across the spectrum of medical disciplines, serving as a key reference source for research scientists in their quest for new diagnostics and more effective therapeutics. Evidence is accumulating that these cell-derived vesicles present in eukaryotic fluids have specialized functions and play a key role in physical processes ranging from coagulation to intercellular signalling and beyond. There is growing interest in clinical applications, with the potential for use in prognosis, therapy, and as biomarkers for health and disease. The exosome revolution may well be the greatest advance in physiology and medicine since antibiotics, and the discovery of their epigenetic role in intercellular signalling in all tissues is a major breakthrough in our understanding of how cells operate. In particular, exosomes offer an advance in diagnosis and treatment of a wide range of illnesses, including cancer. Yet with the literature growing so rapidly across so many disparate fields, it is a challenge for researchers and clinicians to easily gain a firm grounding on the topic. A comprehensive reference source on this topic will fill an enormous gap in disseminating this new knowledge in one packet to a very large audience. Provides readers with both general overviews to get oriented to exosomes and state of In a rapidly expanding field, summarizes laboratory findings and their applications in health and pathological conditions, offering readers a solid foundation of findings thus farEdited and authored by a global team of experts in each relevant discipline in order to present a complete story of the exosome biology INDICE: 1. Exosome Basic Mechanisms 2. Methods for exosome isolation and characterization 3. Bacterial Infections 4. Cancer 5. Exosomes as intercellular communication messengers for cardiovascular and cerebrovascular diseases 6. Exosomes in Cutaneous Biology and Dermatologic Disease 7. Fibrosis 8. Hematologic malignancies: the exosome contribution in tumor progression 9. HIV 10. Mechanisms of exosome-mediated immune cell crosstalk in inflammation and disease 11. Exosomes in Metabolic Syndrome 12. Nephrology 13. Exosomes in brain diseases 14. Organ Development 15. Parasitic Diseases 16. Prostate 17. MSC-exosomes in regenerative medicine 18. Reproductive Medicine and Pregnancy 19. Exosomes in Respiratory Disease 20. Retinal Diseases 21. Theragnostics 22. Exosomes, Gemmules, Pangenesis and Darwin 23. Prospects for Exosomes

• ISBN: 978-0-12-816053-4
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 450
• Fecha Publicación: 01/11/2019
• Nº Volúmenes: 1
• Idioma: Inglés