The cancer degradome: proteases and cancer biology

This book will aim to cover recent knowledge of the composition of the Degradome, how it can be studied using modern approaches such as transcriptomics andmass spectrometry; how gene knockout mice have improved our knowledge of the roles of proteases in cancer; how their activity can be imaged both in vitro and in vivo; the links that have emerged between proteolysis and cell signalling; how the degradome can be a useful source of diagnostic and prognostic markers; and finally new approaches to targeting proteolysis for therapy. In the context of the battle against cancer, the Degradome is important in three principal areas: Cellular proteases and their inhibitors are components of the molecular machinery of malignancy, and thus are attractive as therapeutic targets. Importantly, we now appreciate that some proteases perform functions that antagonize tumour growth, and these are then anti-targets that must be avoided INDICE: From the contents Section 1: The Degradome and its analysis.- Section 2: Insights into Protease function.- Section 3: The interface between Proteolysis and Cell Signalling.- Section 4: The degradome as source of cancer diagnostic and prognostic markers.- Section 5: Novel therapeutic strategies.

• ISBN: 978-0-387-69056-8
• Editorial: Springer
• Encuadernacion: Cartoné
• Páginas: 1000
• Fecha Publicación: 01/09/2008
• Nº Volúmenes: 1
• Idioma: Inglés