Drug Discovery in Cancer Epigenetics is a practical resource for scientists involved in the discovery, testing, and development of epigenetic cancer drugs. Epigenetic modifications can have significant implications for translational science as biomarkers for diagnosis, prognosis or therapy prediction. Most importantly, epigenetic modifications are reversible and epigenetic players are found mutated in different cancers; therefore, they provide attractive therapeutic targets. There has been great interest in developing and testing epigenetic drugs, which inhibit DNA methyltransferases, histone modifying enzymes or chromatin reader proteins. The first few drugs are already FDA approved and have made their way into clinical settings. This book provides a comprehensive summary of the epigenetic drugs currently available and aims to increase awareness in this area to foster more rapid translation of epigenetic drugs into the clinic. Highlights the potential of epigenetic alterations in cancer for drug developmentCovers the tools and methods for epigenetic drug discovery, preclinical and clinical testing, and clinical implications of epigenetic therapyProvides important information regarding putative epigenetic targets, epigenetic technologies, networks and consortia for epigenetic drug discovery and routes for translation INDICE: I. Introduction1. Basic epigenetic mechanisms and phenomena2. Cancer epigeneticsII. Methods and Tools for Epigenetic Drug Development3. Deciphering the epigenome latest technologies4. Drug discovery methods5. Animal and clinical testingIII. Classes of Epigenetic Drugs6. DNA Methyltransferase inhibitors7. HDAC and HAT inhibitors8. Histone methyltransferase and demethylase inhibitors9. Inhibitors targeting chromatin readers10. Natural compounds as epigenetic drugs11. Inhibitors targeting long non-coding RNAs12. Additional drugs impacting on epigeneticsIV. Clinical Implications of Epigenetic Therapy 13. Efficacy of combined epigenetic therapies14. Predicting and monitoring response to epigenetic drugs15. Epigenetic Resensitization to Chemotherapy and Radiation 16. Epigenetic BiomarkersV. Networks and Consortia for Epigenetic Drug Discovery17. Structural Genomics Consortium18. Cancer Genome Atlas Network19. Roadmap Epigenomics Project20. Epigenetic Drug discovery programs in pharmaceutical industry
- ISBN: 978-0-12-802208-5
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 498
- Fecha Publicación: 29/01/2016
- Nº Volúmenes: 1
- Idioma: Inglés