NMR in Pharmaceutical Science

NMR in Pharmaceutical Sciences is intended to be a comprehensive source of information for the many individuals that utilize MR in studies of relevance to the pharmaceutical sector. The book is intended to educate and inform those who develop and apply MR approaches within the wider pharmaceutical environment, emphasizing the toolbox that is available to spectroscopists and radiologists. This book is structured on the key processes in drug discovery, development and manufacture, but underpinned by an understanding of fundamental NMR principles and the unique contribution that NMR (including MRI) can provide. After an introductory chapter, which constitutes an overview, the content is organised into five sections. The first section is on the basics of NMR theory and relevant experimental methods. The rest follow a sequence based on the chronology of drug discovery and development, firstly ?Idea to Lead? then ?Lead to Drug Candidate?, followed by ?Clinical Development?, and finally ?Drug Manufacture?.  The thirty one chapters cover a vast range of topics from analytical chemistry, including aspects involved in regulatory matters and in the prevention of fraud, to clinical imaging studies. Whilst this comprehensive volume will be essential reading for many scientists based in pharmaceutical and related industries, it should also be of considerable value to a much wider range of academic scientists whose research is related to the various aspects of pharmaceutical R&D; for them it will supply vital understanding of pharmaceutical industrial concerns and the basis of key decision making processes. INDICE: Contributors xi .Series Preface xvii .Preface xix .Part A: Introduction 1 .1 Drug Discovery and Development: The Role of NMRJeremy R. Everett 3 .Part B: NMR Theory & Experimental Methods 21 .2 Modern NMR Pulse Sequences in Pharmaceutical R&DJohn A. Parkinson 23 .3 Experimental NMR Methods for Pharmaceutical Research and DevelopmentAnthony C. Dona 41 .4 19F NMR Spectroscopy: Applications in Pharmaceutical StudiesJohn C. Lindon and Ian D. Wilson 53 .5 Quantitative NMR Spectroscopy in Pharmaceutical R&DUlrike Holzgrabe 63 .6 High–throughput NMR in Pharmaceutical R&DJohn C. Hollerton 79 .7 Multivariate Data Analysis Methods for NMR–based Metabolic Phenotyping in Pharmaceutical and Clinical ResearchKirill A. Veselkov, James S. McKenzie, and Jeremy K. Nicholson 89 .Part C: Idea to Lead 103 .8 The Role of NMR in Target Identification and Validation for Pharmaceutical R&DKrishna Saxena and Harald Schwalbe 105 .9 High–resolution MAS NMR of Tissues and CellsLeo L. Cheng 117 .10 NMR Studies of Inborn Errors of MetabolismSarantos Kostidis and Emmanuel Mikros 131 .11 NMR–based Structure Confirmation of Hits and Leads in Pharmaceutical R&DPhilip J. Sidebottom 147 .12 Fragment–based Drug Design Using NMR MethodsLeonor Puchades–Carrasco and Antonio Pineda–Lucena 155 .13 Hit Discovery from Natural Products in Pharmaceutical R&DOlivia Corcoran 173 .Part D: Lead to Drug Candidate 183 .14 NMR–based Structure Determination of Drug Leads and CandidatesTorren M. Peakman 185 .15 Mixture Analysis in Pharmaceutical R&D Using Hyphenated NMR TechniquesIan D. Wilson and John C. Lindon 197 .16 Conformation and Stereochemical Analysis of Drug MoleculesGary J. Sharman 207 .17 NMR Methods for the Assignment of Absolute Stereochemistry of Bioactive CompoundsJose M. Seco and Ricardo Riguera 221 .18 Applications of Preclinical MRI/MRS in the Evaluation of Drug Efficacy and SafetyThomas M. Bocan, Lauren Keith, and David M. Thomasson 255 .19 Practical Applications of NMR Spectroscopy in Preclinical Drug Metabolism StudiesRaman Sharma and Gregory S. Walker 267 .20 Preclinical Drug Efficacy and Safety Using NMR SpectroscopyMuireann Coen and Ian D. Wilson 281 .21 Characterization of Pharmaceutical Compounds by Solid–state NMRFrederick G. Vogt 297 .22 Structure–based Drug Design Using NMRMark Jeeves, Lee Quill, and Michael Overduin 317 .23 Pharmaceutical Technology Studied by MRIDavid G. Reid and Stephen J. Byard 331 .Part E: Clinical Development 345 .24 NMR–based Metabolic Phenotyping for Disease Diagnosis and StratificationBeatriz Jiménez 347 .25 NMR–based Pharmacometabonomics: A New Approach to Personalized MedicineJeremy R. Everett 359 .26 Clinical MRI Studies of Drug Efficacy and SafetyDavid G. Reid, Paul D. Hockings, and Nadeem Saeed 373 .27 The Role of NMR in the Protection of Intellectual Property in Pharmaceutical R&DFrederick G. Vogt 385 .Part F: Drug Manufacture 395 .28 Analysis of Counterfeit Medicines and Adulterated Dietary Supplements by NMRMyriam Malet–Martino and Robert Martino 397 .29 Pharmaceutical Industry: Regulatory Control and Impact on NMR SpectroscopyAndrea Ruggiero and Sarah K. Branch 413 .30 NMR Spectroscopy in the European and US PharmacopeiasHelen Corns and Sarah K. Branch 425 .31 NMR in Pharmaceutical ManufacturingEdwin Kellenbach and Paulo Dani 441 .Index 453

• ISBN: 978-1-118-66025-6
• Editorial: Wiley–Blackwell
• Encuadernacion: Cartoné
• Páginas: 504
• Fecha Publicación: 18/09/2015
• Nº Volúmenes: 1
• Idioma: Inglés