Molecular, Cellular, and Metabolic Fundamentals of Human Aging

Molecular, Cellular, and Metabolic Fundamentals of Human Aging provides researchers with an overview of the main aging mechanisms and physiology and how they can lead to age-related diseases and conditions. Topics covered include DNA damage and how ineffective repair can lead to cell and tissue aging and decreased functionality, loss of proteostasis, changes to feeding and fasting pathways, mitochondrial dysfunction, the impact of decreased ability of autophagosomes and autophagosomes, cellular senescence, changes to communication molecules, and the impact of stem cell exhaustion. The book also considers the impact of aging within the immune system, the relationship between aging and diseases such as cancers and neurodegenerative conditions, and provides an overview on the dialogue surrounding the topic of aging beyond basic biology. Covers the basic hallmarks of aging and their relevance in various diseases, such as cancer and Alzheimer's disease Discusses the impact of genetic damage and how changes in genetic expression patterns affect the process of aging Highlights recurring themes and key principles shared across the hallmarks of aging Considers NAD+ depletion and defective autophagy as emerging aspects that  impact human aging INDICE: 1. Introduction and the hallmarks of aging Section I. The Genome 2. Genomic instability 3. Telomere attrition 4. Epigenetic alterations Section II. Metabolism, Homeostasis and Communication 5. Altered cellular communication 6. Deregulated nutrient sensing 7. Loss of proteostasis Section III. Autophagy and Bioenergetics 8. Compromised autophagy and mitophagy 9. Mitochondrial dysfunction Section IV. Senescence 10. Cellular senescence and stem cell exhaustion Section V. Applications 11. Ageing and the immune system 12. Pharmaceutical treatment

• ISBN: 978-0-323-91617-2
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 365
• Fecha Publicación: 01/11/2022
• Nº Volúmenes: 1
• Idioma: Inglés