Analytical Assessment of E-Cigarettes: From Contents to Chemical and Particle Exposure Profiles

Analytical Assessment of e-Cigarettes: From Contents to Chemical and Particle Exposure Profiles addresses the many issues surrounding electronic cigarettes in an unprecedented level of scientific detail. The plethora of product devices, formulations, and flavors, combined with the lack of industry standards and labeling requirements, quality control, and limited product oversight, has given rise to public concern about initiation of use and potential for adverse exposure and negative long-term health outcomes. This volume discusses how analytical methods can address these issues and support the manufacturing, labeling, distribution, testing, regulation, and monitoring for consistency of products with known chemical content and demonstrated performance characteristics. The book begins with the background on aerosol drug delivery services and e-cigarettes, constituents of nicotine-containing liquid dosing formulations, typical use scenarios and associated aerosol emissions, and chemical exposures and pharmacological and toxicological effect profiles, and then continues with descriptions of the analytical methods used to characterize the chemicals in formulations and emissions from e-cigarettes, including their stability, physical particle-size distribution and thermal degradation under commonly employed conditions of use. Analytical methods enabling detection of biomarkers of exposure and harm in complex biological matrices are discussed, with an emphasis on constituents or emissions of current medicinal interest or with potential to produce harm. Opportunities and challenges for analytical chemistry in supporting the continued development and use of safe and consistent dosage formulations as alternatives to tobacco products are also explored, with a concluding section describing an analytical approach to a risk-benefit assessment of e-cigarette use on human health. Discusses the chemistry and physics involved in aerosol production, inhalation, deposition, chemical exposure, and effect assessmentContains current information and state-of-the-science methods on e-cigarette emissions, exposures, and harm assessmentOffers an authoritative, objective perspective from five of the most well-recognized scientists in their areas of expertise who have no personal stake in the e-cigarette industry or the opposition INDICE: 1. Introduction to e-Cigarettes History of devices, device function, and overview of product types Konstantinos E. Farsalinos 2. Analytical Testing of e-Cigarette Aerosols Yield profiles of disposable personal vaporizers, variable voltage/wattage and temperature-controlled devices, sample generation and collection methods, and liquid vs. aerosol composition Gene Gillman 3. Measurement Methods for Aerosol Constituents Determining precisely the size of primary particles and thermal degradants, and of other constituents of current interest Jonathan W. Thornburg 4. Biomarkers and Assessment of Chemical Exposure from e-Cigarette Emissions Determining the type, amount and biological significance of constituents of primary and secondary emissions, and documenting tissue exposure, with emphasis on carcinogenicity and adverse health impact Stephen S. Hecht 5. Review of Compounds of Regulatory Concern Specific attention to those constituents discussed in Chapter 4 that are known or suspected toxicants or have pharmacological effects but are not regulated as drugs (e.g., nicotine) Konstantinos Farsalinos 6. Risk Assessment of e-Cigarettes The potential impact of e-cigarettes usage on public health Riccardo Polosa

• ISBN: 978-0-12-811241-0
• Editorial: Elsevier
• Encuadernacion: Rústica
• Páginas: 150
• Fecha Publicación: 01/11/2016
• Nº Volúmenes: 1
• Idioma: Inglés