V(D)J Recombination: for the community of immunologists and developmental biologists, the molecular route by which B and T lymphocytes acquire their uniquefunction of affording adaptive immunity. Yet, for many – from experienced scientists to trainees – it represents a (rather too) sophisticated process whosetrue insight is excessively demanding. However, when not simply considered asa private ground for a few aficionados, it can be seen as a way of understanding how mature lymphocytes carry on their basic functions. For the group of aficionados – which includes this editor – it is an elegant paradigm featuring many fascinating evolutionary achievements of which the biological world alone has the secret. These include a subtle biochemical principle most likely hijacked some 470 million years ago from an ancestral gene invader and since then cleverly adapted by jawed vertebrates to precisely cleave and rearrange their antigen receptor (Ig and TCR) loci. INDICE: From the contents 1. Early Steps of V(D)J Rearrangement: Insights from Biochemical Studies of RAG-RSS Complexes. 2. Regulation of RAG Transposition. 3. Recent Insights into the Formation of RAG-Induced Chromosomal Translocations. 4. V(D)J Recombination Deficiencies. 5. Large-Scale Chromatin Remodeling at the Immunoglobulin Heavy Chain Locus: A Paradigm for Multigene Regulation. 6. Genetic and Epigenetic Control of V Gene Rearrangement Frequency. 7. Dynamic aspects of TCRa gene recombination: qualitative and quantitative assessments of the TCRa chain repertoire in Man and mouse. 8. Germline Transcription: A Key Regulator of Accessibility and Recombination. 9. Dynamic Regulation of Antigen Receptor Gene Assembly. 10. Molecular Genetics at the T-Cell Receptor bLocus: Insights into the Regulation of V(D)J Recombination. 11. Molecular Pathways and Mechanisms Regulating the Recombination of Immunoglobulin Genes during B-Lymphocyte Development.
- ISBN: 978-1-4419-0295-5
- Editorial: Springer
- Encuadernacion: Cartoné
- Páginas: 215
- Fecha Publicación: 01/06/2009
- Nº Volúmenes: 1
- Idioma: Inglés