Renal cell carcinoma: translational biology, personalized medicine, and novel therapeutic targets

This book provides a comprehensive look at renal cell carcinoma, exploring its biology as well as current and future molecular targets for renal cancer carcinoma. Provides a comprehensive look at renal cell carcinoma. Explores renal cellcarcinoma biology. Discusses future molecular targets for renal cancer carcinoma. INDICE: Preface. The Genetic Basis of Kidney Cancer and Implications for Targeted Therapies. Molecular Biology of Clear Cell Renal Carcinoma. HIF Biology in RCC: Implications for Signaling, Disease Progression, and Treatment. Tissue Biomarkers in Renal Cell Carcinoma: Intermediate Endpoints in the Selection of Targeted Agents for RCC. Molecular Characterization of Renal Cell Carcinoma. Targeting The Vegf Pathway In Renal Cell Carcinoma. Angiopoetins and OtherNon-VEGF Antiangiogenic Targets In Advanced Renal Cell Carcinoma. Towards Personalized Cancer Medicine. Epigenetic Targeting and Histone Deacetylase Inhibition in RCC. C-MET as a Novel Target for the Treatment of Renal Cell Carcinoma. Characterizing and Modulating the Tumor Micro-Environment in Renal Cell Carcinoma: Potential Therapeutic Strategies. Carbonic Anhydrase IX: Its role as abiomarker, diagnostic, and therapeutic target in Renal Cell Carcinoma. Presurgical Therapy for Renal Cell Carcinoma and Implications for Window of Opportunity Trials. Mechanisms of Resistance to VEGF Directed Therapy and Implicationsfor Future Trial Design. Vaccine Based Immunotherapy and Targeting the Tumor Microenvironment in Renal Cell Carcinoma. Index.

• ISBN: 978-1-4614-2399-7
• Editorial: Springer New York
• Encuadernacion: Cartoné
• Páginas: 270
• Fecha Publicación: 31/03/2012
• Nº Volúmenes: 1
• Idioma: Inglés