Receptors in the Evolution and Development of the Brain: Matter into Mind

Receptors in the Evolution and Development of the Brain: Matter into Mind presents the key role of receptors and their cognate ligands from an evolutionary developmental biology perspective that demonstrates the plausible theory for correctly wiring the mammalian brain. It discusses the key functions of receptors in the evolution and development of the nervous system in the large vertebrate brain. The key role of receptors in wiring the brain is emphasized, along with rapid eye movement sleep and apoptosis as mechanisms to destroy mis wired neurons. Finally, the possibility that connectional diseases including Alzheimer's, Parkinson's, and ALS result from trophic deficits is discussed. This book is extremely useful to those with an interest in the molecular and cellular neurosciences, including those in cognitive and clinical branches of this subject, but is also ideal for all readers who have a curiosity about the incredibly complex human brain and how it can build itself. Provides an understanding of the key role receptors play in brain development and the selection process necessary to construct a large brainTraces the evolution of receptors, from the most primitive organisms to humansEmphasizes the roles that REM sleep and apoptosis play in this selection via trophic factors and receptorsDescribes the role that trophic factor-receptor interactions play throughout life and how trophic deficits can lead to connectional diseases, including Alzheimer's, Parkinson's and ALSProvides a potential mechanism whereby neuronal stem cells can cure these diseases INDICE: 1. Introduction 2. Receptors and their Functions 3. The RNA World and First Cells 4. Receptor Functions in Archaea and Bacteria 5. Dictyostelium Discoidium 6. Chaonoflagella 7. Sponges 8. Hydra 9. Cell Biology of Neurons 10. Myelinated Axons 11. Rapid Eye Movement Sleep 12. Apoptosis 13. The Theory 14. Trophic Factors 15. Neuronal Stem Cells 16. Summary and Conclusions

• ISBN: 978-0-12-811012-6
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 300
• Fecha Publicación: 01/11/2018
• Nº Volúmenes: 1
• Idioma: Inglés