Epigenomics in Health and Disease discusses the next generation sequencing technologies shaping our current knowledge with regards to the role of epigenetics in normal development, aging, and disease. It includes the consequences for diagnostics, prognostics, and disease-based therapies made possible by the study of the complete set of epigenetic modifications to the genetic material of human cells. With coverage pertinent to both basic biology and translational research, the book will be of particular interest for medical and bioscience researchers and students seeking current translational knowledge in epigenesis and epigenomics. Coverage includes the latest findings on epigenome-wide research in disease-based profiling, epidemiological implications, epigenome-wide epigenetic studies, the cancer epigenome, and other pervasive disease categories. Presents critical reviews that provide the means for reviewing and analyzing the epigenome as a whole, also discussing its translational potentialCombines basic epigenomic knowledge with methodological and biostatistical topics related to technology and data analysisIncludes coverage of relatively new topics, including DNA methylation dynamics during development and differentiation, genome-wide histone post-translational modifications during development and differentiation, and genome-wide DNA methylation changes during aging INDICE: 1. An Introduction to Epigenetics2: The Study of the Epigenome: Technical Approaches3: Epigenomics vs genomics: effects of the tissue specificity and stability over time4: DNA Methylation Microarrays5: Ultra Deep Sequencing of Bisulfite Modified DNA6: Bioinformatic Tools in Epigenomic Studies7: Genome-Wide Non-Coding RNA Regulation of Health and Disease8: Genome-Wide DNA Methylation Changes During Aging9: The Dynamics of Histone Modification During Aging10: Epigenomic Studies in Epidemiology11: The DNA Methylomes of Cancer12: Genome-Wide Epigenetic Studies in Neurological Disorders13: Epigenomic Profiling in Diseases of the Immune System14: Genome-Wide DNA and histone Modification Studies in Metabolic Disease15: Clinical Applications of Epigenomics
- ISBN: 978-0-12-800140-0
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 304
- Fecha Publicación: 01/10/2015
- Nº Volúmenes: 1
- Idioma: Inglés